抗凝血酶Ⅲ与急性冠脉综合征的关系研究  

Relationship between Antithrombin-Ⅲ and Acute Coronary Syndrome

作　　者：赵顺芳[1] 尹雪艳[1] 崔敏[1] 宇伯诚[1] 

机构地区：[1]大理学院附属医院,云南大理671000

出　　处：《大理学院学报（综合版）》2011年第12期57-59,共3页Journal of Dali University

摘　　要：目的:探讨AT-Ⅲ水平与急性冠脉综合征的相关性。方法:选择ACS患者53例,分AMI组42例和UA组11例,与60例健康体检者进行对照,测定AT-Ⅲ:Ag含量,进行对比研究。结果:ACS的AT-Ⅲ水平明显低于对照组,而AMI组较UA组的AT-Ⅲ水平低,且有统计学意义(P<0.05)。ACS患者治疗后AT-Ⅲ水平增高。结论:ACS患者AT-Ⅲ水平降低,甚至与冠状动脉病变程度成正比,测定其水平有助于反映体内高凝状态,判断疾病预后,进行用药疗效评估。Objective： To explore the relationship between antithrombin Ⅲ and acute coronary syndrome（ACS）.Methods： Fifty-two consecutive patients with ACS were enrolled in the study,42 cases were acute myocardial infarction（AMI）,and 11 cases were unstable angina（UA）,and 60 healthy subjects were chosen as controls.The plasma level of antithrombin Ⅲ was measured in all subjects.Results： The levels of antithrombin Ⅲ in ACS patients group was significantly lower compared to the healthy control;and the patients with AMI showed lowest levels of antithrombin Ⅲ.The levels of antithrombin Ⅲ increased significantly after comprehensive treatment of ACS.Conclusion： Plasma levels of antithrombin Ⅲ decreased in ACS patients.The measurement of antithrombin Ⅲ could be a reflection of hypercoagulation state,and it is helpful in prognosis and treatment.

关 键 词：抗凝血酶Ⅲ 急性冠脉综合征 急性心肌梗死 不稳定型心绞痛 

分 类 号：R541.4[医药卫生—心血管疾病]