Malyngamides类海洋天然产物合成研究进展  

Recent progress in the total synthesis of malyngamides

作　　者：张军涛[1] 齐宪亮[1] 曹小平[1] 

机构地区：[1]兰州大学功能有机分子化学国家重点实验室,兰州730000

出　　处：《中国科技论文在线》2011年第12期877-886,共10页

基　　金：高等学校博士学科点专项科研基金资助项目(20090211110007);高等学校学科创新引智计划资助项目(111-2-17);国家重点基础研究发展计划(973计划)资助项目(2010CB833203);国家自然科学基金资助项目(20872055;20972060)

摘　　要：从蓝藻中分离的malyngamides类化合物因其独特的化学结构和良好的生物活性,吸引了有机化学家极大的关注,笔者一直致力于malyngamides类海洋天然产物的全合成研究,完成了其中几类代表性分子的全合成。笔者根据结构上的不同将malyngamides分为3类,并综述了各类中具有代表性分子的合成策略,详细地列出每条合成路线的关键反应及产率等。Malyngamides isolated from the marine cyanophyte Lyngbya majuscula have attracted a great deal of attentions among organic chemists, because these natural products were found to possess a unique structure and a wide range of biological properties. We focused our interest on the synthesis of these molecules, several types of which have already been prepared in our lab. In this paper, the malyngamides was classified into three categories based on the structures. The synthetic strategies of these moleculues were reviewed, and the key reaction and the yields of these synthetic routes were also reviewed briefly.

关 键 词：有机化学 malyngamides 全合成 Johnson-Claisen重排 Henry反应 ALDOL反应 Nozaki-Hiyama-Kishi反应 FRIEDEL-CRAFTS反应 WITTIG反应 SUZUKI偶联 

分 类 号：O621.25[理学—有机化学]