血清β_2微球蛋白对早期糖尿病肾病的诊断价值探讨  

Evaluation of Serum β_2-MG as a Marker in Diagnosis of Early Diabetic Nephropathy

作　　者：刘璐[1] 曾娇娥[1] 

机构地区：[1]长江大学荆州临床医学院荆州市中心医院内分泌科,湖北荆州434020

出　　处：《长江大学学报（自然科学版）》2011年第12期145-146,6,共2页Journal of Yangtze University(Natural Science Edition)

摘　　要：目的:探讨β2-微球蛋白(β2-MG)在糖尿病肾病早期诊断中的临床价值。方法:采用免疫比浊法测定糖尿病(DM)65例患者的血清β2-MG浓度,同时测定尿白蛋白排泄率(UAER)、γ-痕迹蛋白(SCysC)作为对照,判断在早期糖尿病肾病中的临床意义和应用价值。结果:UAER升高组(早期糖尿病肾病组)血清β2-MG浓度明显高于UAER正常组(P<0.01),并与UAER及血清SCysC浓度呈显著正相关。结论:血清β2-MG与UAER及血清SCysC具有相同的临床意义,可以作为诊断早期糖尿病肾病的一项更简便、快速的敏感指标。Objective:To investigate the values of serum β2-MG concentration in the diagnosis of early diabetic nephropathy.Methods:β2-MG concentration and urinary albumin excretion(UAE) and SCysC were measured in 65 patients with diabetes mellitus by partical-enhanced turbidimetric immunoassay.Relationship between the two parameters was evaluated.Results:β2-MG was positively correlated with UAE and SCysC.Conclusion:β2-MG,along with UAE and SCysC,was found to be a useful indicator and a sensitive marker in the diagnosis of early diabetic nephropathy.

关 键 词：Β2-微球蛋白 尿白蛋白排泄率 Γ-痕迹蛋白 糖尿病肾病 

分 类 号：R587.1[医药卫生—内分泌]