痹痛灵颗粒对胶原诱导性关节炎大鼠的影响  

Influences of Bitongling Granule on Collagen-induced Arthritis Rats

作　　者：覃仕化[1] 汪悦[2] 

机构地区：[1]南京中医药大学 [2]南京中医药大学第一临床医学院,江苏南京210029

出　　处：《湖北中医药大学学报》2011年第6期8-10,共3页Journal of Hubei University of Chinese Medicine

摘　　要：目的观察痹痛灵颗粒对胶原蛋白诱导性关节炎大鼠肿瘤坏死因子α(TNF-α)的影响。方法以牛Ⅱ型胶原蛋白和完全弗氏佐剂造成胶原蛋白诱导性关节炎大鼠模型,称取各组大鼠造模当天及给药结束当天的体质量;测定各组大鼠血清中及组织匀浆中TNF-α含量。结果痹痛灵高剂量组能明显抑制关节炎大鼠血清及组织中的TNF-α的含量,且与甲氨蝶呤比较无明显差异。结论痹痛灵颗粒对类风湿关节炎有较好的抑制作用。Objective To explore the mechanisms of Bitongling Granule on the collagen - induced arthritis rats. Methods Bovine collagen type II and complete Freund＇s adjuvant were used for making collagen - induced arthritis in rats. The rats were weighed after modeling and treatment. Levels of TNF - a of serum and tissue homogenate. Resdts Bitongling high dose group significantly reduced serum and tissue levels of TNF - a , with insignificant difference with methotrexate. Conclusion Bitongling Granule has good inhibitory effect on rheumatoid arthritis.

关 键 词：胶原诱导性关节炎 痹痛灵颗粒 肿瘤坏死因子Α 

分 类 号：R285.5[医药卫生—中药学]