天山雪莲透皮微乳制备处方优化  

Optimization of Preparation Formulation of Saussurea involucrate Transdermal Microemulsion

作　　者：谢敏[1] 邢建国 王新春[1,3] 樊鑫梅[1] 马晓莉[1] 

机构地区：[1]石河子大学药学院,新疆石河子832002 [2]新疆维吾尔自治区药物研究所,乌鲁木齐830004 [3]石河子大学医学院第一附属医院,新疆石河子832008

出　　处：《中国实验方剂学杂志》2012年第1期8-11,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：自治区科技支疆计划项目(201091156)

摘　　要：目的:优化天山雪莲水包油型微乳处方。方法:以芦丁及绿原酸为指标,采用HPLC测定天山雪莲提取物在各溶媒中的溶解度,初步确定处方组成,绘制伪三元相图对处方进行优化,测定优化处方的黏度、平均粒径、粒径分布等理化性质。结果:Km=1∶2时,伪三元相图形成的微乳区域最大,微乳最佳处方为RH40-1,2-丙二醇-油酸的比例4∶2∶1,微乳平均粒径及黏度符合透皮微乳的要求,在高温、强光下无分层,无絮凝或药物析出。结论:天山雪莲微乳增加了天山雪莲提取物的溶解度,具有粒径小、稳定性好、黏度适宜的特点。Objective：To optimize formulation of O/W microemulsion of Saussurea involucrate. Method： Both chlorogenic acid and turin used as indexes, solubility in various solvents of extracts from S. involucrate was determined by HPLC, and obtained primary compositions of microemulsion formulation, formulations of S. involucrate microemusion was optimized by practicing pseudoternary phase diagram and determined its quality including viscosity, conductivity, refractive index, zeta potentia, particle size distribution respectively. Result： Maximum area of microemulsion in pseudo-ternary phase diagrams was obtained when Km was 1 ：2. Optimum microemusion formulation was RH 40 as surfactant, alchol as cosurfactant and oleic acid as oil phase with its proporation as 4： 2： 1. Viscosity and mean particle size of S. involucrate microemulsion accorded with requirement of transdermal microemuslion. It was stable under high temperature and strong light condition（non-hierarchical, non- flocculation or precipitation of drug）. Conclusion： Solubility of extracts from S. involucrate was improved by microemulsion, This microemulsion had characteristics of small particle,stability and suitable viscosity etc.

关 键 词：天山雪莲 微乳 伪三元相图 

分 类 号：R283.6[医药卫生—中药学]