白术水煎液制备工艺优选及炒制对水煎成分的影响  

Optimization of Preparation Technology of Decoction from Atractylodis macrocephalae and Effect of Stir-baked with Soil to Boiled Ingredients of Decoction

作　　者：陈鸿平[1] 陈林[1] 徐同利[1] 刘友平[1] 李博[1] 

机构地区：[1]成都中医药大学药学院,中药材标准化教育部重点实验室,中药资源系统研究与开发利用省部共建国家重点实验室培育基地,成都610075

出　　处：《中国实验方剂学杂志》2012年第1期28-32,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：四川省教育厅青年基金项目(2006B024);成都中医药大学校基金项目(ZRYB200933,ZRYB201022)

摘　　要：目的:优选白术水煎液最佳提取工艺,在此基础上研究炒制对白术水煎液中成分溶出的影响。方法:以白术内酯Ⅰ,Ⅱ,Ⅲ含量和水溶性总糖的含量综合评分为指标,采用L9(34)正交设计法优选白术水煎液最佳制备工艺。并按优选条件分别制备白术、清炒白术和土炒白术水煎液,比较各水煎液中总糖、白术内酯Ⅰ,Ⅱ,Ⅲ的含量及煎出率。结果:优选的最佳水煎工艺条件为14倍量水,煎煮3次,每次1 h。炒后白术水煎液中总糖含量、白术内酯Ⅰ,Ⅱ,Ⅲ总含量均明显增高,与生品相比有极显著差异;在总糖含量指标上,土炒品明显高于清炒品。结论:白术与辅料土共同加热炮制后更有利于其化学成分煎出。Objective：To optimize extraction technology of decoction from Atractylodis macrocephalae,and at this basis researched effect of processing with soil on the content and extracting rate of effective constituents.Method：L9（3）4 orthogonal method was employed to optimize extracted technology by using the content in composite score of soluble sugar and atractylenolide Ⅰ,Ⅱ,Ⅲ as indexes.And respectively prepared decoction from raw A.macrocephalae、fried A.macrocephalae and soil-fried A.macrocephalae by this optimum extraction conditions,then compared the content and extracting rate of total sugar and atractylenolide Ⅰ,Ⅱ,Ⅲ in standard decoction of each processed A.macrocephalae.Result：Optimum extraction process was：boiled 3 times with 14 times amount of water,1 hour each time.The content of soluble sugar and atractylenolide Ⅰ,Ⅱ,Ⅲ were significantly increased in these processed products.There was significant difference between raw product and processed product.The content of soluble sugar in soil-fried product were significantly higher than that in fried product.Conclusion：It showed that being heated with soil could beneficial to boiling chemical composition.

关 键 词：白术 炮制 提取工艺 土炒 

分 类 号：R283.6[医药卫生—中药学]