川芎对豆腐果苷的促吸收与增效作用研究  

The Study on Promotion of Absorption and Synergistic Effect of Chuanxiong Rhizoma with Helicid

作　　者：苏柘僮[1] 徐佳丽[1] 刘英[1] 杨胜[2] 杨明[1,3] 

机构地区：[1]成都中医药大学,成都610075 [2]成都医学院,成都610083 [3]江西中医学院中药现代制剂教育部重点实验室,南昌330004

出　　处：《中国实验方剂学杂志》2012年第1期176-178,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:对川芎对豆腐果苷的增效进行探索性研究。方法:采用大鼠离体外翻小肠吸收试验,于37℃恒温水浴中实验,以台试液为接收液,以累积渗透量为评价指标,考察川芎对豆腐果苷吸收情况的影响;采用硝酸甘油致大鼠偏头痛模型,以一次性sc硝酸甘油10 mg.kg-1造模,以5-羟色胺(5-HT)、降钙素基因相关肽(CGRP)为评价指标,考察川芎对豆腐果苷药效的影响。结果:川芎可将豆腐果苷累积渗透量从53.72μg提高至335.48μg,可显著增加豆腐果苷的药效(P<0.05)。结论:川芎不仅对豆腐果苷起到吸收促进作用,还兼有增效的作用,显示了中药的"药辅合一"作用。Objective：To study synergistic effect of Chuanxiong Rhizoma with helicid.Method：Using in vitro absorption model of rat,effects of Chuanxiong Rhizoma on absorption of helicid were observed and accumulation absorptive amount（Q） was calculated.Rat migraine model was induced by nitroglycerin,level of 5-HT and CGRP were measued.Result：Q value of helicid with rhizoma chuanxiong was enhanced from 53.72 μg to 335.48 μg,increased pharmacodynamic action（P〈0.05）.Conclusion：Chuanxiong Rhizoma not only promote absorption of helicid,but increase pharmacodynamic action.Thus,the research result demonstrates the function of ＇unification of drug and adjuvant＇.

关 键 词：豆腐果苷 川芎 药辅合一 

分 类 号：R285.5[医药卫生—中药学]