冠心通脉胶囊对冠心病患者动脉粥样硬化相关细胞因子的影响  

Effects of Guanxin Tongmai Capsule on Cytokinesrelated to Atherosclerosis in Patients with Coronary Heart Disease

作　　者：雷健[1] 吴勇宏[2] 陈烈[3] 张耕[1] 柯于鹤[1] 

机构地区：[1]武汉市第一医院心血管内科,武汉430022 [2]六安市中医院心血管内科,安徽六安237006 [3]湖北中医药大学,武汉430065

出　　处：《中国实验方剂学杂志》2012年第1期210-212,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：武汉市卫生局项目(武卫[2007]43号)

摘　　要：目的:观察冠心通脉胶囊对冠心病心绞痛患者白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、内皮细胞微颗粒(EMPs)和血管性血友病因子(vWF)含量的影响,探讨其可能的作用机制。方法:将60例冠心病心绞痛患者随机分为治疗组(冠心通3粒/次,3次/d)和对照组(通心络胶囊,3粒/次,3次/d),4周为1个疗程,比较2组临床疗效以及服药前后IL-6,TNF-α,EMPs,vWF含量变化。结果:心电图观察显示,治疗组总有效率85.7%,对照组总有效率90.0%,2组间无显著性差异;临床疗效治疗组总有效率92.9%,对照组总有效率93.3%,2组间无显著性差异;治疗组和对照组的IL-6,TNF-α,EMPs,vWF治疗后均下降明显,前后比较有显著性差异(P<0.01),2组间比较无显著性差异。结论:冠心通脉胶囊能明显降低冠心病心绞痛患者IL-6,TNF-α,EMPs,vWF的含量,在治疗冠心病心绞痛疗效上与通心络胶囊相当,其作用机制可能与抗炎症反应有关。Objective：To observe the levels of Guanxin Tongmai capsule on interleukin 6（IL-6）,tumor kecrosis fator-α（TNF-α）,endothelial cells micro particles（EMPs） and von willebrand factor（vWF） in patients with coronary heart disease and the action mechanism of Guanxin Tongmai capsule.Method：Sixty patients were divided randomly into treatment group（Guanxin Tongmai capsule 3# Tid） and control group（Tongxinluo capsule 3# Tid）.After 4 weeks treatment,the results of IL-6,TNF-α,EMPs and vWF and the clinical effects were compared between the two groups.Result：There were no significant difference between the treatment group（85.7%）and the control group（90.0%） on ECG,no significant difference between the treatment group（92.9%）and the control group（93.3%） on clinical effect.The content of IL-6,TNF-α,EMPs and vWF in the two groups were both significantly decreased after treatment,no statistically significant difference between the two groups.Conclusion：Guanxin Tongmai capsule could decrease the content of IL-6,TNF-α,EMPs and vWF in the patients with coronary heart disease.Guanxin Tongmai capsule can play a considerable role compared with Tongxinluo capsule,the action mechanism may be anti-inflammatory.

关 键 词：冠心通脉胶囊 冠心病 细胞因子 内皮细胞微颗粒 血管性血友病因子 

分 类 号：R287[医药卫生—中药学]