阿托伐他汀钙对老年单纯收缩期高血压患者脉压的影响  

Effect of Atorvastatin Calcium on Pulse Pressure in Senile Patients with Isolated Systolic Hypertention

作　　者：陈群[1,2] 赵艳芳[2] 刘平[2] 徐建新[2] 宫剑滨[1] 

机构地区：[1]南京大学医学院,南京210093 [2]中国人民解放军第81医院心内科,南京210002

出　　处：《医学综述》2011年第24期3806-3808,共3页Medical Recapitulate

摘　　要：目的观察阿托伐他汀钙对老年单纯收缩期高血压(ISH)患者脉压(PP)的影响。方法选取我院2009年3月至2010年10月住院治疗的老年ISH患者80例,随机分为两组:对照组(A组)40例,口服氨氯地平5 mg;治疗组(B组)40例,口服氨氯地平5 mg,阿托伐他汀钙10 mg。观察20周,每2周记录1次血压。结果治疗20周后,两组收缩压(SBP)均已达标,B组SBP和PP较A组降低更显著,B组优于A组,两组比较有统计学意义(P<0.05);24 h平均SBP、舒张压、PP均明显下降,组内比较差异有统计学意义(P<0.05),两组间比较24 h平均SBP、PP其差异有统计学意义(P<0.05)。结论阿托伐他汀钙有助于改善老年ISH患者的PP,可能进一步降低心脑血管事件的危险性。Objective To observe atorvastatin calcium effect on pulse pressure （PP）in senile patients with isolated systolic hypertension（ISH）. Methods 80 senile patients with ISH hospitalized in our hospital during March 2009 to October 2010 were selected and randomly divided into 2 groups. Amlodipine 5 mg/d was taken by 40 subjects in control group （A）. 40 subjects in treatment group（ B ）were administered with amlodipine 5 mg/d and atorvastatin calcium 10 mg/d orally. Blood PP was followed-up and recorded every 2 weeks for 20 weeks. Results After 20 weeks treatment, SBP in both the groups have reached the standard, SBP and PP of B group decreased more significantly than in group A, B group better than in group A with sta- tistically significant difference （ P 〈 0.05 ） ;24 h average SBP, DBP, PP decreased significantly, the difference within each group was statistically significant（P 〈0.05）; differences of 24 h average SBP,PP between the two groups were statistically significant （ P 〈 0.05 ）. Conclusion Atorvastatin calcium is helpful to the PP improvement in senile patients with ISH ,which may further reduce cardiovascular event risk.

关 键 词：阿托伐他汀钙 单纯收缩期高血压 脉压 

分 类 号：R544.1[医药卫生—心血管疾病]