高密度脂蛋白胆固醇、低密度脂蛋白胆固醇及其比值检测在中老年冠心病患者诊断和临床治疗中的意义  

Significance of serum HDL-C,LDL-C,LDL-C/HDL-C ratio levels in middle-and elderly-aged patients with coronary heart disease

作　　者：纵静[1,2] 唐其柱[1,2] 周恒[1,2] 

机构地区：[1]武汉大学人民医院心血管内科 [2]武汉大学心血管病研究所,湖北武汉430060

出　　处：《临床荟萃》2012年第1期31-34,共4页Clinical Focus

基　　金：中央高校基本科研业务费专项资金(20103020201000193)

摘　　要：目的探讨血清高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、LDL-C/HDL-C检测在中老年冠心病(CHD)患者中的意义。方法分析经冠状动脉造影确诊为冠状动脉粥样硬化(药物治疗组)83例、CHD(支架植入组)163例及冠状动脉造影阴性(对照组)44例中老年病例的血清HDL-C、LDL-C、LDL-C/HDL-C比值与冠状动脉病变程度之间的关系。并比较各组间男女血脂水平的差异。结果药物治疗组、支架植入组与对照组总胆固醇(TC)、LDL-C、LDL-C/HDL-C比值水平差异有统计学意义(P<0.05或<0.01)。支架植入组TC、LDL-C、TC/HDL-C比值水平明显高于药物治疗组及对照组(P<0.05或<0.01)。支架植入组HDL-C显著低于药物治疗组及对照组(P<0.05)。药物治疗组女性HDL-C水平高于男性(P<0.05),但女性TC/HDL-C比值、LDL-C/HDL-C比值低于男性(P<0.05)。支架植入组女性TC和HDL-C高于男性(P<0.05)。对照组女性TC、HDL-C高于男性(P<0.05),但女性TG/HDL-C、LDL-C/HDL-C低于男性(P<0.05)。结论血清HDL-C、LDL-C、LDL-C/HDL-C比值与冠状动脉病变相关,对中老年CHD患者的诊断及临床治疗有使用价值。Objective To appraise the significance of serum high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C） and low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio（LDL-C/HDL-C） in middle-and elderly-aged patients with coronary heart disease（CHD）.Methods Association between HDL-C,LDL-C and LDL-C/HDL-C ratio and coronary artery lesions were analyzed in 290 patients who underwent coronary arteriongraphy,including coronary atherosclerosis diagnosed in 83 patients,given drug treatment,CHD confirmed in 163 patients who took PCI and negative in 44 cases as control group.And the differences among the three groups of males and females in blood lipid levels were analyzed.Results The levels of total cholesterol（TC）,LDL-C and LDL-C/HDL-C ratio among the three groups were statistically different（P0.05 or 0.01）.Stent group had higher TC,LDL-C,TC to HDL-C ratio（TC/HDL-C） than drug treatment group and controls（P0.05 or 0.01）.Stent group had significantly lower HDL-C than drug treatment group and controls（P0.05）.HDL-C level of females in drug treatment group was significantly higher than that of males（P0.01）,but TC/HDL-C and LDL-C/HDL-C ratios of females in controls were lower than those of males（P0.05）.TC and HDL-C levels of females in stent group were higher than those males（P0.05）.TC and HDL-C levels of females in controls were higher than those of males（P0.05）,but TG/HDL-C and LDL-C/HDL-C of females decreased more than those of males（P0.05）.Conclusion Serum HDL-C,LDL-C and LDL-C/HDL-C ratio associated with coronary artery lesions,and they were useful predicting indexes of clinical diagnosis and treatment for middle-and elderly-aged CHD patients.

关 键 词：冠状动脉疾病 冠状血管造影术 胆固醇 HDL 胆固醇 LDL 

分 类 号：R541.4[医药卫生—心血管疾病]