2-氟-6-甲氧基苯甲酸的合成  

Synthetic Research on 2-Fluoro-6-Methoxybenzoic Acid

作　　者：田兆军[1] 蒋云霞[1] 杨春和[1] 

机构地区：[1]南通农业职业技术学院环境与资源系,江苏南通226007

出　　处：《化工生产与技术》2011年第6期4-5,7,共2页Chemical Production and Technology

摘　　要：采用2,6-二氟苯甲腈经甲氧基化、水解反应得2-氟-6-甲氧基苯甲酸,研究了工艺条件对每步反应的影响。结果表明,甲氧基化时甲醇钠与2,6-二氟苯甲腈反应适宜的摩尔比为0.95:1.00,收率为85.4%;2-氟-6-甲氧基苯甲腈水解反应适宜的条件为:反应时间>1.5 h,盐酸酸化pH<5,此时收率79.2%;目标产品结构经红外光谱仪、核磁共振仪确认,总收率67.6%,纯度98.9%。该方法收率较高,简单可行,具备工业化条件。2-Fluoro-6-methoxybenzoic acid was synthesized from 2,6-difluorobenzonitrile via methoxylation and hydrolysis with an overall yield of about 67.6% and purity of 98.9%.The influences of technological conditions to each step reaction were researched.The results showed that the appropriate mole ratio of sodium methoxide and 2,6-difluorobenzonitrile was 0.95:1 in methoxylation reaction,the yield was 85.4%;The appropriate reaction conditions of 2-fluoro-6-methoxybenzonitrile hydrolysis were: reaction time >1.5 h,pH<5,the yield was 79.2%;The structure of the target product was identified by IR and 1H NMR.This method had high yield,simple and feasible,suit for industry production.

关 键 词：2-氟-6-甲氧基苯甲酸 2 6-二氟苯甲腈 2-氟-6-甲氧基苯甲腈 合成 

分 类 号：TQ245.3[化学工程—有机化工]