浙江大学儿童医院左乙拉西坦片处方分析  

Analysis of Levetiracetam Prescriptions in Children's Hospital of Zhejiang University

作　　者：赵雷[1] 王玉梅[1] 高向波[1] 叶伟峰[1] 

机构地区：[1]浙江大学医学院附属儿童医院,浙江杭州310003

出　　处：《儿科药学杂志》2012年第1期23-27,共5页Journal of Pediatric Pharmacy

摘　　要：目的:分析我院门诊左乙拉西坦片使用情况,为合理用药提供参考。方法:对我院门诊2010年11～12月左乙拉西坦片电子处方进行统计,分析用药合理性。结果:共检索到目标处方269张,涉及患儿208例。4岁以下患儿处方65张,占总处方的24.16%;诊断为癫痫的处方256张,占95.17%;18岁以下体重小于50 kg的患儿处方266张,其中单次剂量小于10 mg/(kg.次)的处方65张,占24.44%;左乙拉西坦单药治疗的患儿占32.69%。结论:我院左乙拉西坦应用无年龄限制;临床诊断与用法用量基本合理;左乙拉西坦单药治疗癫痫有一定应用;电子处方系统需要优化或细分;建议配备更适合儿童应用的剂型;用于4岁以下患儿或单药治疗时建议从用药的安全性、有效性方面充分权衡利弊,以达到合理用药。Objective： To analyze the use of levetiracetam tablets in outpatients of our hospital,and provide a reference for the rational use of medicines.Methods： Levetiracetam electronic prescriptions to outpatients of our hospital from November to December 2010 were statistically analyzed.Results： Totally 269 prescriptions were found,with 208 children involved.In these 269 prescriptions,65 prescriptions for children under 4 years old,accounting for 24.16% of total prescriptions;256 prescriptions for patients diagnosed with epilepsy,accounting for 95.17%;266 prescriptions for children weighing less than 50 kg,of which 65 prescriptions for each dosage less than 10 mg/kg,accounting for 24.44%;32.69% of children received levetiracetam monotherapy.Conclusions： Use of levetiracetam in our hospital had no age limit;clinical diagnosis and dosage were reasonable;levetiracetam monotherapy for epilepsy had some application;electronic prescription system needs to be optimized or subdivided;more suitable formulations for children should be provided;when levetiracetam is used for children under 4 years old or as monotherapy,it is recommended that the safety and effectiveness should be weighed in order to achieve rational drug use.

关 键 词：左乙拉西坦 癫痫 儿童 单药治疗 处方分析 

分 类 号：R971.6[医药卫生—药品]