艾片的体外黏膜渗透性及影响因素研究  

Study on in vitro mucosal factors affecting mucosal permeability of borneol

作　　者：宋逍[1,2] 杜守颖[1] 陆洋[1] 马勇[1] 陈晓兰[1] 

机构地区：[1]北京中医药大学中药学院,北京100102 [2]陕西中医学院药学院,西安712046

出　　处：《中华中医药杂志》2012年第1期87-90,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金面上项目(No.81073057);"重大新药创制"科技重大专项(No.2009ZX09502-008);中药生产技术及过程控制技术标准平台(No.2009ZX09308-003);教育部博士点基金(No.20090013110007);北京中医药大学创新团队发展计划~~

摘　　要：目的:考察艾片的体外黏膜渗透性及影响因素。方法:选择离体牛蛙腹皮为渗透模型,采用改良的Franz扩散池进行体外黏膜实验;GC测定艾片中龙脑的含量,研究接收液的不同pH值、温度、搅拌速度及药物浓度对艾片体外黏膜渗透的影响。结果:搅拌速度对艾片的渗透有一定的影响;而接收液的pH值、温度及药物浓度对艾片的渗透无影响。艾片黏膜渗透性良好,累积渗透率与时间符合一级吸收过程。结论:离体牛蛙腹皮可作为艾片的体外黏膜渗透性研究的实验模型。Objective： To study the in vitro mucosal factors that affect such permeability of borneol.Method： Bullfrog skin was selected as the permeation model,and the modifiled Franz diffusion was adopted to investigate the percutaneous adsorption in vitro.borneol as quantified by GC.Different of pH receiving solution and temperature,mixings peed and impacts of drug concentration on percutaneous adsorption invitro were systematically studied.Result： Percutaneous permeation of borneol was to some extent affected by mixings peed.Other fctors had no effect on the penetration of borneol.There existed a good percutaneous of borneol.And the relationship between the cumulative permeability rate and time was coincided with the first order kenetical process.Conclusion： Taken the in vitro abdominl skin of bullfrog as the permeation model,which were study on in vitro mucosal factors affecting mucosal permeability of borneol.

关 键 词：艾片 离体蛙皮 黏膜渗透 表观渗透系数 

分 类 号：R285[医药卫生—中药学]