冠心病中医证型与大内皮素、N末端脑钠肽的相关性  

Correlative study between TCM syndromes of coronary heart disease and big endothelin-1,N-terminal probrain natriuretic peptide

作　　者：任毅[1] 陈可冀[2] 张敏州[1] 尤士杰[3] 郭力恒[1] 张健[3] 吕渭辉[1] 

机构地区：[1]广东省中医院,广州510120 [2]中国中医科学院西苑医院,北京100091 [3]中国医学科学院阜外心血管病医院,北京100037

出　　处：《中华中医药杂志》2012年第1期207-209,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家中医药行业科研专项基金(No.200707004)~~

摘　　要：目的:探讨冠心病中医证型与大内皮素(Big ET-1)及N末端脑钠肽(NT-proBNP)之间的相关性。方法:将405例冠心病患者按中医辨证为气虚、阴虚、阳虚、气滞、血瘀、寒凝、痰浊7个证型,检测其血浆BigET-1和NT-proBNP水平,并进行比较。结果:血瘀及兼证、非血瘀证两组比较,Big ET-1差异有统计学意义(P<0.05);阳虚及兼证、非阳虚证两组比较,寒凝及兼证、非寒凝证两组比较,NT-proBNP差异有统计学意义(P<0.05);冠心病不同西医分型比较,NT-proBNP差异有统计学意义(P<0.05)。结论:血瘀证可能和Big ET-1相关,阳虚证、寒凝证可能和NT-proBNP相关,Big ET-1、NT-proBNP可能作为冠心病辨证分型的客观指标。Objective： To explore the relativity between TCM syndromes of coronary heart disease（CHD） and the plasma concentration of big endothelin-1（Big ET-1）,N-terminal probrain natriuretic peptide（NT-proBNP）.Methods： 405 CHD patients were divided into 7 TCM syndromes,Qi deficiency syndrome（QDS）,Yang asthenia syndrome（YAS）,Yin deficiency syndrome（YDS）,Qi stagnation syndrome（QSS）,cold coagulation syndrome（CCS）,blood stasis syndrome（BSS） and phlegm-turbid syndrome（PTS）,and the plasma concentrations of Big ET-1 and NT-proBNP were measured and compared.Results： Differences of NT-proBNP have statistics significance in comparison between BSS and accompanied syndromes and non-BSS（P0.05）;Differences of Big ET-1 had statistics significance in comparison between YAS and accompanied syndromes and non-YAS（P0.05）,and between CCS and accompanied syndromes and non-CCS（P0.05）.Conclusion： BSS possibly had a relationship with Big ET-1,YAS and CCS were possibly correlation with NT-proBNP,Big ET-1 and NT-proBNP possibly were biochemistry material base of different TCM syndromes of CHD.

关 键 词：冠心病 中医证型 内皮素 脑钠肽 

分 类 号：R259[医药卫生—中西医结合]