深静脉血栓患者血清抗心磷脂抗体水平的检测  

Anticardiolipin Antibodies Assay in Blood of 40 Cases of Deep Venous Thrombosis

作　　者：徐朝阳[1] 石聪聪[1] 李涛[1] 白峻宇[1] 贺颖[1] 郑红[1] 

机构地区：[1]郑州大学医学院细胞生物学与医学遗传学教研室,郑州450052

出　　处：《河南职工医学院学报》2011年第5期510-511,共2页Journal of Henan Medical College For Staff and Workers

摘　　要：目的检测深静脉血栓形成(DVT)患者血清抗心磷脂抗体的水平,探讨静脉血栓的发生机制。方法用酶联免疫吸附法(ELISA)检测40例DVT患者与40例健康对照血清抗心磷脂抗体IgA,IgM,IgG的水平,并进行统计分析。结果 DVT组抗心磷脂抗体ACA-IgM(0.52 0.35),ACA-IgG(0.78 0.42)的水平均显著高于对照组ACA-IgM(0.31 0.22),ACA-IgG(0.43 0.29)(P<0.01);DVT组抗心磷脂抗体的总阳性率(52.5%)显著高于对照组(17.5%)(P<0.01)。结论抗心磷脂抗体水平的增高可能是深静脉血栓形成的危险因素。Objective To learn the level of anticardiolipin antibodies（ACA） in cirumferential blood in 40 cases of deep venous thrombosis（DVT）,discuss the occurring mechanism of venous thrombosis.Methods The writers performed a case-control study to detect ACA in 40 samples of DVT and 40 samples of control with ELISA.Results The level of ACA-IgM（0.52±0.35）,ACA-IgG（0.78±0.42）in DVT group was much higher than the level of ACA-IgM（0.31±0.22）,ACA-IgG（0.43±0.29） in control group（P〈0.01）.The total positive ratio of ACA in DVT group（52.5%） was much higher than that of（17.5%） was in control group（P〈0.01）.Conclusion Maybe it can provide reference value to assay the level of ACA in patients of deep venous thrombosis.

关 键 词：抗心磷脂抗体 深静脉血栓形成 酶联免疫吸附法 

分 类 号：R543.6[医药卫生—心血管疾病]