阿托品治疗急性有机磷农药中毒的荟萃分析  

Meta analysis of atropine in treatment of acute organophosphorus poisoning

作　　者：张华林[1] 张丽莎[2] 黄瑾[1] 胡晋红[1] 

机构地区：[1]第二军医大学长海医院药学部,上海200433 [2]第二军医大学图书馆,上海200433

出　　处：《药学服务与研究》2011年第6期456-458,共3页Pharmaceutical Care and Research

基　　金：国家科技支撑计划(No.2009DAI76D030211)

摘　　要：目的:分析和评价阿托品在临床上用于有机磷农药中毒的治疗效果。方法:收集了33篇以阿托品为试验组,盐酸戊乙奎醚(商品名长托宁)为对照组治疗有机磷农药中毒的文献,对结果进行荟萃(Meta)分析,评价指标采用优势比(OR)及其95%可信区间(95%CI),统计学分析采用RevMan 4.220软件。结果:阿托品与盐酸戊乙奎醚在治疗有机磷农药中毒时治愈率的差异存在统计学意义,其OR值为0.21,95%Cl为0.15～0.30。结论:相对于阿托品,盐酸戊乙奎醚对有机磷农药中毒的治疗更加有效。Objective： To analyze and evaluate the therapeutic effectiveness of atropine in treatment of acute organophos phorus poisoning（AOPP）. Methods： Thirty-three articles about atropine（test group） and penehyclidine hydrochloride（control group） in treatment of AOPP were collected and studied by Meta analysis. Odds ratio（OR） and its 95% confidence interval（CI） were used as the measure parameters of the therapeutic effectiveness. The statistical analysis was performed by RevMan 4. 220 soflware. Results： The therapeutic effectiveness of atropine and penehyclidine hydrochloride in treatment of AOPP were signifi cantly different with OR 0.21 and 95 % CI 0. 15-0.30. Conclusion： Penehyclidine hydrochloride is more effective than atropine in treatment of AOPP.

关 键 词：阿托品 盐酸戊乙奎醚 急性有机磷农药中毒 药物疗法 META分析 

分 类 号：R595.4[医药卫生—内科学]