南京大学医学院附属鼓楼医院2010年698例药品不良反应回顾性分析  

Retrospective analysis of 698 case reports of adverse drug reactions in 2010 of Drum Tower Hospital affiliated to School of Medicine,Nanjing University

作　　者：徐红[1] 徐丽华[1] 

机构地区：[1]南京大学医学院附属鼓楼医院药剂科,南京210008

出　　处：《药学服务与研究》2011年第6期459-461,共3页Pharmaceutical Care and Research

摘　　要：目的:分析药品不良反应(ADRs)发生的情况和原因,制定防范措施。方法:运用Excel软件对南京大学医学院附属鼓楼医院698例ADRs报告分类统计分析,计算ADRs发生例数、ADRs例数与其用药频度(DDDs)的比值(相对发生率)。结果:抗感染药引起的ADRs为264例(37.82%),其中左氧氟沙星73例居首位,其次为循环系统药113例(16.19%)和抗肿瘤药92例(13.18%)。用药频度(DDDs)则抗感染药中的左氧氟沙星排序第一,ADRs例数/DDDs比值排序的均值抗肿瘤药为8.5,排序第一。ADRs的临床表现以皮肤及附件损害最为常见,共255例(36.53%)。结论:须进一步加强ADRs的监测,并做好相应的防范措施,减少或避免ADRs发生。Objective：To analyze the status and reasons of adverse drug reactions（ADRs） in Drum Tower Hospital affiliated to School of Medicine, Nanjing University, and make precautions. Methods： Six hundred and ninety-eight reports of ADRs were analyzed retrospectively by Excel software. The numbers of ADRs,the ratios of numbers of ADRs and DDDs were calculated. Results ： The numbers of ADRs induced by anti infection drugs was 264 cases （37.82 % ）, among which, levofloxacin （73 cases） ranked the first, followed by circulatory system drugs （113 cases,16.19%） and anti-tumor drugs （92 cases,13.18%）. The DDDs of levofloxacin also ranked the first. The orders of average relative incidence ratio of anti-tumor drugs was 8. 5, which ranked the first. The main clinical manifestations of ADRs were the damage of the skin and accessory with 255 cases（36. 53%）. Conclusion：Monitoring ADRs should be strengthened and we should make precautions to decrease or avoid the occur rence of ADRs.

关 键 词：药物副反应报告系统 用药频度 药学服务 

分 类 号：R994.13[医药卫生—毒理学]