不同pH值条件下环丙沙星-聚氨酯前药的水解释药研究  

The Research on Hydrolyzation and Drug Release of Ciprofloxacin-Polyurethane in Different pH Values

作　　者：温志国[1] 李春艳[2] 胡从从[2] 黄剑华[3] 董声雄[1,3] 

机构地区：[1]福州大学化学化工学院,350108 [2]福建医科大学药学院,福州350108 [3]宁德师范学院化学与环境科学系,宁德352100

出　　处：《聚氨酯工业》2011年第6期17-20,共4页Polyurethane Industry

摘　　要：研究了不同载药率的环丙沙星-聚氨酯(CFPU)前药抗菌材料在37℃、不同pH值条件下的水解释药情况。结果表明,载药率为16.2%时,在不同pH值条件下的降解释药量都比较大,不利于药物的保留。载药率为8.3%和13.5%时,在不同pH值条件下降解较少,药物的保留比较好。The antibacterial ciprofloxacin-polyurethane （CFPU） prodrug with different drug content hydrolysis and release under different pH values at 37 ℃ was studied. The results showed that the CFPU drug release was more large under different pH values which was not favorable for the reverse of the drug when the drug content was 16.2%. When the CFPU drug content was 8.3% and 13.5% , the CFPU drug release was more smaller and had good drug reverse rate.

关 键 词：CFPU前药 抗菌 控制释放 聚氨酯 水解 

分 类 号：R943[医药卫生—药剂学]