胚胎干细胞向内皮细胞分化  

Differentiation of embryonic stem cells into endothelial cells

作　　者：韩雷[1] 苗俊英[1] 苏乐[1] 

机构地区：[1]山东大学生命科学学院,济南250100

出　　处：《生命的化学》2011年第6期772-778,共7页Chemistry of Life

摘　　要：心血管疾病是目前引起死亡的主要原因之一,血管再生和细胞治疗为治愈心血管疾病带来了希望。胚胎干细胞作为内皮细胞和组织工程材料的来源,为治疗心血管疾病提供了广泛的应用前景。本文详细讲解胚胎干细胞向内皮细胞定向诱导分化的方法、信号通路及相关的转录调控因了,为研究定向诱导胚胎干细胞向血管内皮细胞分化提供系统的方法和理论指导,同时为利用胚胎干细胞来源的内皮细胞治疗心血管疾病提供了理论基础。Cardiovascular disease is one of the main causes of death worldwide. Vascular regeneration and cell therapy provide promising prospect for treating cardiovascular disease. Embryonic stem cells are now the main sources of endothelial cells and tissue engineering materials for cell therapy. In this paper, we reviewed the methods, signaling pathways and transcription factors during the process of embryonic stem cells differentiation into endothelial cells. It provides a systematic approach and theoretical guidance for studying differentiation of embryonic stem cells into vascular endothelial cells. Furthermore, it lays a theoretical basis for treating cardiovascular disease by using endothelial cells induced by embryonic stem cells.

关 键 词：胚胎干细胞 血管内皮细胞 转录调控因子 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]