mTOR信号通路调节HIF-1α及VEGF  

mTOR signaling pathway regulates HIF-1α and VEGF

作　　者：陈洪菊[1,2] 唐彬秩[1,2] 屈艺[1,2] 母得志[1,2] 

机构地区：[1]四川大学华西第二医院儿科,成都610041 [2]四川大学华西第二医院妇儿疾病与出生缺陷教育部重点实验室,成都610041

出　　处：《生命的化学》2011年第6期838-843,共6页Chemistry of Life

基　　金：国家自然科学基金项目(30825039;30973236;81172174);教育部长江学者和创新团队基金(IRT0935);四川省科技厅基金项目(2010SZ0280)资助

摘　　要：哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)是一种非典型丝氨酸/苏氨酸蛋白激酶,可整合营养、能量及生长因子等多种细胞外信号,参与基因转录、蛋白质翻译、核糖体合成等生物过程,在细胞生长和细胞程序性死亡中发挥极为重要的作用。研究表明,mTOR信号通路可能通过调节下游靶蛋白来调控细胞生物过程,如缺氧诱导因子(hypoxia-inducible factor,HIF-1α,血管内皮生长因子(vascular endothelial growth factor,VEGF)等。mTOR通过调节这些细胞因子,可能影响蛋白质合成、血管生成和细胞凋亡自噬等,从而影响疾病发展和结局,这为mTOR成为疾病治疗靶点提供证据。The mammalian target of rapamycin （mTOR） is an evolutionarily conserved atypical Ser/Thr protein kinase, functioning as a sensor of extracellular signals from nutrients, oxygen, energy and growth factors. Through modulating its downstream targets in the cellular nucleus, roTOR regulates transcription, cell growth, protein translation, proliferation, survival and programmed cell death. It is proved that mTOR can regulate the cellular biological processes through some cytokines, such as hypoxia-inducible factor （HIF-1α）, vascular endothelial growth factor （VEGF）, etc. These processes include protein synthesis, angiogenesis, apoptosis or autophagy, which participate in the pathological or survival mechanisms of diseases. Therefore, roTOR could become a candidate target for treatment of diseases.

关 键 词：哺乳动物雷帕霉素靶蛋白 缺氧诱导因子 血管内皮生长因子 

分 类 号：R341[医药卫生—基础医学]