红景天多糖对长波紫外线致大鼠氧化损伤的保护作用  

Protective Effect of Rhodiola Rosea Polysaccharide on UVA-induced Oxidative Damage in Rats

作　　者：黄冰洋[1] 魏海[1] 周权明[1] 郭婧[1] 钟丽婷[1] 沈楠[1] 姜艳霞[1] 

机构地区：[1]吉林医药学院基础医学院,吉林吉林132013

出　　处：《环境与职业医学》2012年第1期31-33,共3页Journal of Environmental and Occupational Medicine

基　　金：吉林医药学院大学生科研基金(编号:200903)

摘　　要：[目的]探讨红景天多糖对长波紫外线(ultraviolet A,UVA)辐照大鼠损伤的防护效果。[方法]用红景天多糖干预UVA辐射大鼠,检测各组血清、肝脏匀浆中超氧化物歧化物(superoxide dismutase,SOD)、谷胱甘肽(glutathione,GSH),丙二醛(malondialdehyde,MDA)及羟自由基,观察红景天多糖的防护效果。[结果]981.71 J/cm2 UVA辐射组血清中SOD、GSH、抑制羟自由基能力明显低于正常对照组(P<0.05),MDA含量明显高于正常对照组(P<0.05)。经高剂量红景天多糖干预的UVA辐射组血清中GSH和抑制羟自由基能力明显高于UVA辐射组(P<0.05),MDA含量明显低于UVA辐射组(P<0.05);低剂量组MDA含量明显低于UVA辐射组(P<0.05),抑制羟自由基能力明显高于UVA辐射组(P<0.05)。肝组织匀浆中,UVA辐射组SOD活性、抑制羟自由基能力明显低于正常对照组(P<0.05);高剂量组SOD活性、抑制羟自由基能力明显高于UVA辐射组(P<0.05),MDA含量明显低于UVA辐射组(P<0.05)。[结论]红景天多糖对UVA辐照所导致的氧化损伤有一定的修复能力,具体机制尚有待进一步研究。[ Objective ] To explore the protective effect of rhodiola rosea polysaccharide on the ultraviolet A （UVA） radiated rats. [ Methods ] The UVA radiated rats were interfered with rhodiola rosea polysaccharides and detected for superoxide dismutase （SOD）, glutathione （GSH）, malondialdehyde （MDA） and hydroxyl radical in serum and liver homogenate to observe the role of rhodiola rosea polysaceharide in protection. [ Results ] The serum SOD, GsH and inhibition ability of hydroxyl radical in 981.71J/cm2 UVA group were significantly lower than that in control group （P〈0.05）, but MDA in that test group was higher than that in control group （P〈 0.05）. In the high dose rhodiola rosea polysaccharide group, serum GSH and inhibition ability of hydroxyl radical were significantly higher than that in UVA radiation group （P 〈 0.05）, and MDA was signifieantly slower than that in UVA radiation group （P 〈 0.05）; while in the low dose rhodiola rosea polysaccharide group, MDA was obviously lower （P 〈 0.05） and inhihition ability of hydroxyl radical was significantly higher （P 〈 0.05） than that in UVA radiation group. In the liver homogenate, SOD activity and hydroxyl radical inhibition ability in UVA radiation group were significantly lower than that in control group （P 〈 0.05）, and that in high dose rhodiola rosea polysaccharide group were significantly higher than that in UVA radiation group （P 〈 0.05）, but MDA was obviously lower （P 〈 0.05）. [ Conclusion ] Rhodiola rosea polysaceharide has definite ability to repair UVA radiation damage, but its mechanism need to be further studied.

关 键 词：红景天 多糖 长波紫外线 氧化损伤 

分 类 号：R114[医药卫生—卫生毒理学]