国外上市新型注射剂的研究进展  

Progress in the Research of the Novel Injections Marketed Abroad

作　　者：王晓琳[1] 栾瀚森[1] 杨莉[1] 王浩[1] 

机构地区：[1]中国医药工业研究总院药物制剂国家工程研究中心,上海201203

出　　处：《中国医药工业杂志》2012年第1期60-67,共8页Chinese Journal of Pharmaceuticals

摘　　要：纳米粒、微球、脂质体、原位凝胶和微乳或亚微乳等给药系统能减少药物在体内外的降解,实现药物的控制释放。基于上述给药系统的新型注射剂已成为药物研发的关注热点。本文综述了近年国外上市的新型注射剂的剂型特点及其临床应用概况,并介绍了几种新型注射装置。Several drug delivery systems, such as nanoparticles, microspheres, liposomes, in stiu hydrogel, and micro- or submicro-emulsions are endowed with the advantages of lessening degradation of drugs in vitro and in vivo and achieving controllable release profile. Thus, preparation of novel injections based on these delivery systems has been a hot spot in the drug development area. The dosage characteristics of these novel injections marketed abroad in recent years and these clinical applications are reviewed, and some new injection devices are introduced.

关 键 词：新型注射剂 缓控释给药系统 注射装置 综述 

分 类 号：R944.11[医药卫生—药剂学]