熊去氧胆酸与牛磺熊去氧胆酸治疗胆固醇性胆结石的疗效比较  

Comparison of Therapeutic Efficacy of Ursodeoxycholic Acid and Tauroursodeoxycholic Acid for Cholesterol Gallstone

作　　者：朱晨宇[1] 高曰文[1] 朱华[1] 朱耀明[1] 王广胜[1] 

机构地区：[1]三峡大学第一临床医学院/宜昌市中心人民医院普外科,湖北宜昌443002

出　　处：《中国药房》2012年第4期321-322,共2页China Pharmacy

摘　　要：目的:比较熊去氧胆酸(UDCA)和牛磺熊去氧胆酸(TUDCA)治疗胆囊胆固醇性胆结石的疗效及安全性。方法:将74例胆固醇性胆结石患者随机分为2组,分别给予UDCA(每次250mg,每日3次)和TUDCA(每次250mg,每日3次)治疗6个月,分别在治疗3个月和6个月后通过B超对患者的溶石效果进行比较并观察2组不良反应发生情况。结果:经过3个月的治疗,UDCA和TUDCA对胆结石治疗的有效率分别为37.8%和56.8%,6个月治疗的有效率分别为75.7%(28/37)和78.4%(29/37)。2组比较,3个月时TUDCA对胆结石的疗效优于UDCA(P<0.01);但经过6个月的治疗,二者的疗效无显著性差异。2组不良反应发生率比较差异无统计学意义。结论:TUDCA和UDCA均可有效溶解胆固醇性胆结石,且安全性较好,但TUDCA的溶石速度大于UDCA。OBJECTIVE： To compare the safety and therapeutic efficacy of ursodeoxycholic acid （UDCA） and tauroursodeoxy- cholic acid （TUDCA） for cholesterol gallstone. METHODS： 74 patients with cholesterol gallstone were randomly divided into 2 groups. Patients were given UDCA （250mg, tid） or TUDCA （250 rag, tid） for 6 months. The dissolution of cholesterol gallstone was compared by B-ultrasonography at the end of 3rd month and 6th month. RESULTS： After 3 months of treatment, the effective rate was 37.8% in the UDCA group and 56.8% in the TUDCA group, but the effective rate was 75.7% （28/37） in the UDCA group and 78.4% （29/37） in the TUDCA group at the end of 6th month. At the end of 3rd month, TUDCA was more effective than UD- CA （P〈0.01）. At the end of 6th month, the difference was not statistically significant. CONCLUSION： Cholesterol gallstone can be dissolved by both UDCA and TUDCA, and the difference of efficacy is not statistically significant. But the dissolution occur more rapidly with TUDCA.

关 键 词：熊去氧胆酸 牛磺熊去氧胆酸 胆固醇性胆结石 

分 类 号：R657.4[医药卫生—外科学]