体外肿瘤细胞培养及药敏试验对食管癌术后化疗的意义  

The significance of the tumor cell cultured and drug sensitivity test after esophagectomy chemotherapy

作　　者：羽平[1] 张智[1] 

机构地区：[1]重庆市肿瘤研究所胸外科,重庆400030

出　　处：《重庆医科大学学报》2011年第11期1394-1397,共4页Journal of Chongqing Medical University

基　　金：重庆市卫生局医学科研资助项目(编号:2007-2-187)

摘　　要：目的:通过对食管癌术后体外肿瘤细胞培养以及对不同药物及化疗方案的敏感性进行比较,寻找各自有效的、合理的化疗方案,指导食管癌的术后化疗。为个体化治疗提供理论依据。方法:采用组织块培养-终点染色-计算机图像分析(Tissueculture end point staining computer image analysis,TECIA)法对94例食管癌组织标本进行体外培养,并用8种常见化疗药物进行药物敏感性试验,了解其对肿瘤的抑制率,并将结果进行比较。结果:试验药物对食管鳞癌的抑制率各不相同,以紫杉醇类最高,阿霉素最低;单药与联合化疗方案的抑制率比较有显著差异,联合药敏感性高于单药。结论:食管癌的术后化疗,应根据每个食管鳞癌患者肿瘤的药敏结果,尽量选择敏感药物及联合用药的化疗方案。Objective：To guide for searching an effective and reasonable individualized chemotherapy after esophagectomy by the tumor cell cultured and tumor drug sensitivity test.Methods：compared with the inhibitory rate of tumor drug sensitivity test of 94 cases with esophageal cancer,intervered with 8 chemotherapy drugs used commonly in clinic,was determined by TECIA method.Results：The inhibitory rate of 8 chemotherapy drugs are different,PTX obtain best therapy effect,and ADM＇s effect is minimum,and the combined chemotherapy effect is obvious better than a sole chemotherapy.Conclusion：The tumor drug sensitivity test have important value to determine the postoperative chemotherapy,and the treatment should select most sensitive drugs and combined chemotherapy.

关 键 词：食管癌 肿瘤药敏试验 

分 类 号：R979.1[医药卫生—药品]