乙酰左旋肉碱防治奥沙利铂引起的外周神经病变性疼痛的研究  

Acetyl-L-carnitine prevents and reduces oxaliplation-evoked painful peripheral neuropathy

作　　者：刘国凯[1] Gary Bennett 

机构地区：[1]北京中医药大学东直门医院麻醉科,北京100700 [2]加拿大麦吉尔(McGill)大学麻醉科及疼痛中心

出　　处：《中国临床药理学与治疗学》2011年第12期1379-1382,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:观察乙酰左旋肉碱(ALCAR)对奥沙利铂引起的外周神经病变性疼痛的防治效果。方法:选取SD雄性大鼠20只(150～200g),随机分为两组,ALCAR组与安慰剂组,每组各10只;用5%葡萄糖将奥沙利铂溶液稀释到2mg/mL,连续5d(d 0～d 4)腹腔注射2mg/kg。ALCAR(100mg/kg,p.o.)或对照液从0天开始注射(第1天注射奥沙利铂开始),并继续21d(即最后一次奥沙利铂注射后再持续15d)。并于d 0、d 8、d 15、d 22、d 29、d 35及d 41测定机械异常痛敏[4g von Frey hairs(VFH)]和机械痛敏(15g VFH)。结果:与对照组比较,ALCAR组大鼠在d 8、d 15、d 22、d 29、d 35及d 41机械异常痛敏(4g VFH)和机械痛敏明显改善(P<0.01)。结论:ALCAR可防治奥沙利铂引起的大鼠外周神经病变性疼痛。To examine the potential efficacy of acetylLcarnitine （ALCAR） to prevent and treat,oxaliplationevoked pain. METHODS： 20 adult male Sprague-Dawley rats （150 200 g） were randomly divided into two groups, ALCAR group and control group. Each group had 10 rats. A stock solution of oxaliplatin is diluted to 2 mg/mL with 5%dextrose in distilled water and injected IP at 2 mg/kg on five consecutive days （d 0-d 4） in a volume of 1.0 mL/kg. AL CAR （100 mg/kg; p. o. ） or vehicle was given daily starting on day 0 （the day of the first oxaliplatin injection） and continuing until day 21 （i. e., 15 days after the last oxaliplatin injection. Mechanoallodynia and mechanohyperalgesia were assessed using von Frey hairs with bendingforces of 4 g and 15 g, respectively, on d 8, d 22, d27, d35, and d 41postoperatively. Withdrawal responses were counted and expressed as an overall percentage response. RESULTS：Mechanoallodynia （4 g） and mechanohyperalgesia （15 g） of the rats in ALCAR group were significantly and persistently reduced （P〈0.01） on d 8, d 22, d 27, d 35, and d 41 postoperatively in comparison with control group. CONCLUSION： It is concluded that ALCAR may be useful in the prevention and treatment of oxaliplatininduced painful peripheral neuropathy.

关 键 词：乙酰左旋肉碱 奥沙利铂 疼痛 

分 类 号：R614[医药卫生—麻醉学] R965.2[医药卫生—外科学]