中国汉族人群过氧化物酶体增殖物激活受体γ基因Pro12Ala多态性与2型糖尿病相关性的Meta分析  

Meta-analysis of the Association of Pro12Ala Polymorphism of Peroxisome Proliferator Activated Receptorγ Gene with Type 2 Diabetes in Chinese Han Population

作　　者：郭乌兰[1] 唐勇[1] 韩学尧[1] 纪立农[1] 

机构地区：[1]北京大学人民医院内分泌科,北京100044

出　　处：《中国医学科学院学报》2011年第6期593-599,共7页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金(30771031;30570873);国家高技术研究发展计划项目(863项目)(2006AA02A409);国家重点基础研究发展计划项目(973计划)(2005CB523000)~~

摘　　要：目的评价中国汉族人群过氧化物酶体增殖物激活受体γ(PPARγ)基因多态性Pro12A la与2型糖尿病的相关性。方法以"PPARγ"、"pparg"、"Pro12A la"、"type 2 d iabetes"、"Chinese"、"过氧化物酶增殖剂激活受体"、"2型糖尿病"为检索词,全面检索2型糖尿病与Pro12A la相关的文献,用stata 11.0进行Meta分析,对研究数据的优势比(OR)值进行合并,并评价分析结果的可靠性和稳定性。结果 (1)检索到22篇,其中17篇符合纳入标准,包含了3927例2型糖尿患者和3364例正常对照,共7921名。纳入研究人群同质性较好,无显著发表偏倚。(2)次要等位基因A la12在正常人和2型糖尿病患者中的频率分别为4.8%与4.6%。在显性和加性遗传模式下,次要等位基因携带者相对于未携带者的OR值分别为0.95(95%C:I 0.80,1.12)和0.93(95%CI:0.79,1.09)。结论中国汉族人群PPARγ基因多态性Pro12A la与2型糖尿病无相关性。Objective To evaluate the association of Pro12Ala polymorphism of peroxisome proliferator activated receptor γ（PPARγ） gene with type 2 diabetes（T2DM）in Chinese Han population.Methods The present investigation was carried out using the keywords ＂PPARγ＂,＂pparg＂,＂Pro12Ala＂,＂type 2 diabetes＂,and＂Chinese.The odds ratios（OR） for Ala12 used as the metric of choice were calculated in the dominant and additive model separately.The Meta-analysis was conducted by softeware STATA 11.0.Results（1） We identified 22 studies,of which 17 studies involving 3927 type 2 diabetes cases and 3364 controls fell into the inclusion criteria.The analysis indicated no significant inter-study heterogeneity and publication bias.（2） The frequencies of the minor allele Ala12 in type 2 diabetes and control groups were 4.8%and 4.6% respectively.（3） The combined overall OR of dominant and additive model calculated by fix-effects meta-analysis for type 2 diabetes and the Pro12Ala polymorphism,were 0.95（95% CI：0.80,1.12） and 0.93（95% CI：0.79,1.09） respectively.Conclusion In this meta-analysis,the Pro12Ala gene variant（rs1801282） is not found to be associated with the susceptibility for type 2 diabetes in Chinese Han population.

关 键 词：过氧化物酶体增殖物激活受体 PRO12ALA 糖尿病 2型 META分析 

分 类 号：R587.1[医药卫生—内分泌]