人工流产吸宫术前米非司酮的应用和剂量研究  

Dose of mifepristone before vacuum aspiration abortion

作　　者：邢峰[1] 成佳景[1] 刘洁[1] 宋力雯[1] 周健红[1] 

机构地区：[1]同济大学附属第十人民医院妇产科,上海200072

出　　处：《同济大学学报（医学版）》2011年第6期74-76,共3页Journal of Tongji University(Medical Science)

摘　　要：目的研究人工流产吸宫术前服用米非司酮的临床效果及合适剂量。方法选择门诊要求行人工流产的早孕妇女190例,随机分成两组。米非司酮高剂量组98例,术前一日晚20:00口服米非司酮75 mg;米非司酮低剂量组92例,术前一日晚20:00口服米非司酮50 mg。次日上午08:00实施无痛负压吸引术,观察术前出血、胃肠道反应等情况,观察术中宫颈软化、扩张情况,手术用时及出血量的差异。结果两组术前出血、胃肠反应无明显差异。术中宫颈软化、扩张情况、手术用时、出血量比较,差异均有统计学意义。结论人工流产吸宫术前12 h口服米非司酮75 mg,相比口服米非司酮50mg,可使人工流产吸宫术更易扩张宫颈,缩短手术时间,减少出血量,从而更有效的减轻患者的创伤,且药物副作用无明显增加,因此人工流产吸宫术前口服米非司酮75 mg值得推广。Objective To evaluate the clinical efficacy and appropriate dose of mifepristone before vacuum aspiration abortion. Methods One hundred and ninety women undergoing surgical termination of early pregnancy were randomly allocated to 2 groups： 98 cases were given with mifepristone 75 mg 12 h before abortion and 92 cases with mifepristone 50 mg. Adverse effects including vaginal bleeding and gastrointestinal reactions were observed before operation, while the degree of cervical softening, operation time and blood loss were measured during operation in both groups. Results Adverse effects of mifepristone were similar in both groups. The 75 mg group showed better cervical dilation, less operation time and less blood loss during operation than those in 50 mg group （P 〈 0. 05 ）. Conclusion 75 mg mifepristone should be recommended as the appropriate dose for administration before vacuum aspiration abortion.

关 键 词：人工流产 吸宫术 早孕 米非司酮 剂量 

分 类 号：R714.21[医药卫生—妇产科学]