高血压合并OSA患者夜间缺氧与外部形态特征关系  

Correlation of nocturnal hypoxia with body composition in hypertensive patients with obstructive sleep apnea

作　　者：赵普庆[1] 邓兵[2] 艾自胜[3] 曹烨民[4] 乔亮[1] 杨沁彤[4] 

机构地区：[1]上海市中西医结合医院内科,上海200082 [2]同济大学附属同济医院心内科,上海200065 [3]同济大学医学院流行病学与卫生统计学教研室,上海200092 [4]上海市中西医结合医院脉管科,上海200082

出　　处：《同济大学学报（医学版）》2011年第6期95-99,124,共6页Journal of Tongji University(Medical Science)

摘　　要：目的探讨高血压合并阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)患者夜间缺氧与外部形态特征关系。方法高血压合并阻塞性睡眠呼吸暂停患者作为睡眠呼吸暂停组,单纯高血压患者作为高血压组,所入选的患者均行缺氧指标与外部形态特征的检测,比较二组患者缺氧特征和外部形态特征的特点。结果 (1)睡眠呼吸暂停组较高血压组两组患者的体质量、身高、BMI、颈围、腰围、臀围、腰臀比、收缩压、TC、TG、UA及肥胖患病率比较后差异有统计学意义(P<0.05),而两组患者的年龄、舒张压、HDL-C、LDL-C、BUN、Cr、FPG、2hPG及代谢综合征患病率比较后差异无统计学意义(P>0.05)。(2)睡眠呼吸暂停组较高血压组两组患者的缺氧事件总数、缺氧事件总时间、AHI、血氧饱和度<90%的时间、血氧饱和度<90%的缺氧事件总数和睡眠期间血氧饱和度<90%的时间占睡眠时间百分比比较后差异有统计学意义(P<0.05),而两组患者的平均缺氧事件时间、最低血氧饱和度、平均脉搏和最低脉搏比较后差异无统计学意义(P>0.05)。(3)睡眠呼吸暂停组较高血压组体质量、BMI、颈围、腰围、臀围及腰臀比与缺氧事件总数、缺氧事件总时间、AHI、血氧饱和度低于90%的时间及血氧饱和度低于90%的缺氧事件总数呈正相关(P<0.01);体质量、BMI及颈围与睡眠期间血氧饱和度<90%的时间占睡眠时间百分比呈正相关(P<0.05)。结论高血压合并阻塞性睡眠呼吸暂停患者存在夜间缺氧与外部形态特征的改变且有相关性,且二者均参与代谢综合征和高血压。Objective To investigate the correlation of nocturnal hypoxia with body composition in hypertensive patients with obstructive sleep apnea（OSA）.Methods Forty hypertensive patients with OSA（OSA group） and 40 hypertensive patients without OSA（control group） were enrolled in the study.Hypoxic and body composition parameters were measured and compared between two groups. Results The weight,height,body mass index（BMI）,neck circumference,waist circumference,hip circumference,waist-hip ratio,systolic blood pressure,total cholesterol（TC）,triglyceride（TG）,uric acid （UA）and prevalence rate of obesity were much higher in OS A group than those in control group（P 0.05）.There were no significant diffemeces in age,diastolic blood pressure,high density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C）,blood urea nitrogen（BUN）.creatinine （Cr）,fasting plasma glucose（FPG）,2 h plasma glucose（2hPG） and prevalence rate of metabolic syndrome between two groups（P 0.05）.The total number of hypoxic events,the total time of hypoxic events,apnea-hypopnea index（AHI）,the total time of oxygen saturation lower than 90%,the total number of hypoxic events of oxygen saturation lower than 90%and percentage of time of oxygen saturation lower than 90%were higher in OSA groups than those in control group（P 0.05）.There were no significant differences in total time of average hypoxic events,minimal blood oxygen saturation, average pulse and minimal pulse between two groups（P 0.05）.The body composition parameters including weight,body mass index（BMI）,neck circumference,waist circumference,hip circumference and waist-hip ratio were positively correlated with the total number of hypoxic events,the total time of hypoxic events,apnea-hypopnea index（AHI）,the total time of oxygen saturation lower than 90%and the total number of hypoxic events of oxygen saturation lower than 90%（P 0.01）;the weight,body mass index（BMI） and neck circumference were positi

关 键 词：高血压 阻塞性睡眠呼吸暂停 夜间缺氧 外部形态特征 

分 类 号：R541[医药卫生—心血管疾病]