血清SOCS-3、IL-6、TNF-α在溃疡性结肠炎患者中的变化及其相互关系  

Changes in serum levels of SOCS-3,IL-6 and TNF-α and their correlation in patients with ulcerative colitis

作　　者：万国仕[1] 赵振中[1] 钱一龙[1] 谢中华[1] 王珠美[1] 朱建俊[1] 

机构地区：[1]杭州市余杭区第二人民医院,浙江省杭州市311121

出　　处：《世界华人消化杂志》2011年第32期3370-3373,共4页World Chinese Journal of Digestology

摘　　要：目的:观察溃疡性结肠炎(UC)患者血清SOCS-3、IL-6、TNF-α水平变化,探讨其在UC发生发展中的关系及意义.方法:选取UC患者(n=59),其中活动期(n=46),缓解期(n=13),活动期患者中,轻度(n=15),中度(n=24),重度(n=7).采用ELISA法检测各组血清IL-6、TNF-α、SOCS-3含量,并和20例正常体检者进行对照.结果:UC活动组患者血清中IL-6、TNF-α含量均明显高于对照组及缓解组(P<0.01),而血清SOCS-3含量显著低于对照组及缓解组(P<0.01);活动组中,轻、中、重度患者血清IL-6、TNF-α含量随严重程度逐渐升高,血清SOCS-3含量逐渐降低,三级之间差异均具有统计学意义(P<0.05,P<0.01);相关性分析表明,血清IL-6含量与TNF-α含量呈明显正相关(r=0.817,P<0.01);血清SOCS-3含量与IL-6、TNF-α含量均呈明显负相关(r=-0.667、-0.611,P<0.01).结论:UC患者血清SOCS-3水平明显降低,其可能通过负性调节IL-6、TNF-α参与UC的发生发展,且与病情的严重程度有关.AIM：To investigate the changes in the levels of serum suppressor of cytokine signaling-3 （SOCS-3）,interleukin-6（IL-6） and tumor necrosis factor-α（TNF-α） in patients with ulcerative colitis（UC） and to analyze the role of SOCS-3, IL-6 and TNF-αin the genesis and development of ulcerative colitis（UC）. METHODS：According to the severity of UC, 59 patients with UC were divided into active group（n = 46） and remission group（n = 13）. The numbers of patients with mild,moderate, and severe UC in the active group were 15,24 and 7,respectively.Twenty healthy individuals served as normal controls.The levels of serum SOCS-3,IL-6 and TNF-αwere determined by ELISA. RESULTS：The levels of serum IL-6 and TNF-αwere significantly higher and that of serum SOCS-3 was significantly lower in patients in the active group than in those in the remission group and control group（all P 0.01）.The levels of serum IL-6 and TNF-αgradually increased and that of serum SOCS-3 gradually decreased with the aggravation of UC.Significant differences were found in serum levels of SOCS-3, IL-6 and TNF-αamong patients with mild, moderate or severe disease（all P 0.05）.A positive correlation was noted between the levels of serum IL-6 and TNF-α（r = 0.817,P 0.01）,and a negative correlation was observed between serum level of SOCS-3 and those of IL-6 and TNF-α. CONCLUSION：A decrease in serum levels of SOCS-3 in patients with UC may correlate with the progression of UC by negatively regulating serum levels of IL-6 and TNF-α.

关 键 词：溃疡性结肠炎 细胞因子信号转导抑制因子-3 IL-6 TNF-Α 

分 类 号：R581.1[医药卫生—内分泌]