液基薄层细胞学检查可提高宫颈低级别病变检出率  

Increasing the detection rate of cervical lesions of low grade by liquid-based thin-layer cytological detection

作　　者：杨军[1] 陈晓黎[1] 强磊[1] 靳耀锋[1] 赵世平[1] 苏宝山[1] 王康敏[1] 

机构地区：[1]西安交通大学第二附属医院病理科,陕西西安710004

出　　处：《中国妇幼保健》2012年第2期286-288,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨宫颈液基薄层细胞学检查技术(LCT)的应用价值。方法:分析2008年7月2日～2009年1月16日期间西安交通大学第二附属医院LCT检查结果,与同期传统宫颈涂片检查结果对照。结果:LCT阳性率(阳性病例包括L-SIL、H-SIL、SCC、ACC、ASC、AGUS、AGC、HPV感染)13.51%(104/770),其中44例阳性病例行宫颈活检,宫颈组织学检查阳性19例(48.18%)。传统宫颈涂片检查阳性率1.83%(31/1 692),其中22例阳性病例行宫颈活检,宫颈组织学检查阳性11例(50.00%)。对阳性病例病变程度分组分析发现,LCT对HSIL以上高级别宫颈病变(包括HSIL、SCC、ACC)的总体检出率(1.17%,9/770)与传统宫颈涂片检出率(1.30%,22/1 692)差异无统计学意义(P>0.05)。LCT阳性组中病变程度在LSIL以下病例(包括LSIL、ASC、AGUS、HPV感染)占91.35%(95/104),传统宫颈涂片阳性组中病变程度在LSIL以下病例仅占29.03%(9/31),两者之间差异有统计学意义(P<0.05)。通过年龄分组分析,LCT阳性病例中40岁以下者占55.77%,传统宫颈涂片阳性病例中40岁以下病例仅占25.81%,两者之间差异具有统计学意义(P<0.05)。结论:LCT技术可提供高质量细胞学涂片,LCT可显著提高宫颈细胞学检查的阳性率,特别是年轻患者LSIL以下低级别病变的检出率,LCT对宫颈癌的早期发现、诊断将发挥重要的作用。Objective： To explore the application value of liquid - based thin - layer cytological detection technology （LCT） . Methods： The results of LCT from the hospital from July 2, 2008 to January 16, 2009 were analyzed, then the results were compared with those of routine cervical smears. Results： The positive rate of LCT （the positive cases including LSIL, HSIL, SCC, ACC, ASC, AGUS, AGC, and HPV infection） was 13.51% （104/770） , 44 positive cases underwent cervical biopsy, 19 cases （48. 18% ） were found with positive results of cervical histological examination. The positive rate of routine cervical smears was 1.83% （31/1 692）, 22 positive cases underwent cervical biopsy, 11 cases （50. 00% ） were found with positive results of cervical histological examination. The analysis on grouping of degrees of lesions of the positive cases showed that there was no significant difference in the total detection rate of cervical lesions of high grade （including HSIL, SCC, and ACC） between LCT （1.17%, 9/770） and routine cervical smears （1.30%, 22/1 692） （P 〉 0. 05） . The proportions of cases with cervical lesions under LSIL （including LSIL, ASC, AGUS, and HPV infection） accounted for 91.35% （95/104） in LCT positive group and 29.03 % （9/31） in routine cervical smears positive group, there was significant difference between the two groups （P 〈 0. 05 ） . The proportions of cases under forty years old accounted for 55.77% in LCT positive group and 25.81% in routine cervical smears positive group, there was significant difference between the two groups （P 〈 0.05 ） . Conclusion： LCT technology can provide high - quality cytological smears, increase the positive rate of cervical cytological detection, especially for the young patients with cervical lesions under LSIL, LCT plays an important role in early detection and diagnosis of cervical cancer.

关 键 词：液基细胞学 TBS分类 宫颈癌 

分 类 号：R711.74[医药卫生—妇产科学]