从“肺肠合病”模型大鼠血清TNF-α、IL-1含量变化探讨“肺与大肠相表里”  

Discussion on Interior-Exterior Relationship Between Lung And Large Intestine Based on TNF-αand IL-1 Levels Changes In Serum of Rats Model of Combination Disease of Lung And Large Intestine

作　　者：惠毅[1] 杨宇[1] 张显明[1] 郑旭锐[1] 冯贤荣[1] 朱素有[1] 周新颖[1] 

机构地区：[1]成都中医药大学,四川成都610075

出　　处：《辽宁中医杂志》2012年第1期153-154,共2页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)资助项目(2009CB522706)

摘　　要：目的:建立肺病、肠病、肺肠合病大鼠病理模型,通过观察其血清TNF-αI、L-1含量情况,探索"肺与大肠相表里"相关病理机制。方法:实验设正常对照组、肺病组(过敏性哮喘)、肠病组(便秘)和肺肠合病组(过敏性哮喘合便秘)共4组。结果:与正常对照组比较,肺病组、肠病组、肺肠合病组大鼠血清TNF-αI、L-1含量均呈显著性差异(P<0.01);与肺病组比较,肺肠合病组大鼠血清TNF-αI、L-1含量呈显著性差异(P<0.01);与肠病组比较,肺肠合病组大鼠血清TNF-αI、L-1含量呈显著性差异(P<0.01)。结论:肺肠合病组大鼠血清TNF-αI、L-1含量均明显高于肺病组及肠病组,证实TNF-αI、L-1可能是肺与大肠相关的共同物质基础,为"肺与大肠相表里"理论提供一定的现代医学实验依据。Objective ： To establish lung disease rat model, intestine disease model and lung - intestine disease model, through the observation on serum TNF - α and IL - 1 contents changes to explore the pathology mechanism of interior - exterior relation-ship between lung and large intestine. Methods ： There are four groups ： normal control group, lung disease group （ irritablity asthma） ,intestine disease group（constipation） and lung-intestine disease group（irritablity asthma and constipation）. Results：Compared with normal control group, serum TNF - α and IL - 1 contents in lung disease group, intestine disease group and lung - intestine disease group were significantly different（ P 〈 0. 01 ）. Compared with lung disease group, serum TNF -α and IL - 1 con- tents in lung-intestine disease group were significantly different（P 〈 0. 01 ）. Compared with intestine disease group, serum TNF -α and IL - 1 contents in lung - intestine disease group were significantly different（ P 〈 0. 01 ）. Conclusion：Serum TNF - α and IL - 1 contents in lung - intestine disease group are obviously higher than that in disease group and intestine group. It is concluded that TNF - α and IL - 1 may be the basis of the relationship between lung and large intestine, providing modem medical basis.

关 键 词：肺与大肠相表里 TNF-Α IL-1 哮喘 便秘 

分 类 号：R203[医药卫生—中医学]