绣球防风化学成分的研究  

Chemical constituents of Leucas ciliata

作　　者：汪琼[1] 罗士德[2] 徐永艳[1] 

机构地区：[1]西南林业大学园林学院,云南昆明650224 [2]中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,云南昆明650204

出　　处：《中草药》2012年第1期27-31,共5页Chinese Traditional and Herbal Drugs

基　　金：西南林业大学园林学院园林植物与观赏园艺重点实验室资助项目

摘　　要：目的对绣球防风Leucas ciliata的化学成分进行研究。方法利用正相硅胶、RP-18柱色谱、葡聚糖凝胶SephadexLH-20等方法进行分离纯化,根据波谱数据鉴定化合物的结构。结果从绣球防风乙醇提取物中分离得到12个化合物,通过光谱数据分析,分别鉴定为苜蓿素(1)、crisilineol(2)、胡萝卜苷(3)、stigmast-5-ene-11-ol-3-O-β-glucoside(4)、5,7-dimethoxy-2-methyl-4-chromanone(5)、3′,5′,5,7-tetramethoxy-4′-O-β-glucoside flavone(6)、5-hydroxy-3′,4′-dimethoxy-7-O-β-glucoside flavone(7)、acteoside(8)、3,4-dihydroxy-β-phenylethoxy-O-α-L-arabinopyranosyl-(1′′′′→2″)-α-L-rhamnopyranosyl-(1′′′→3″)-4″-O-caffeoyl-β-D-glucopyranoside(9)、3-hydroxy-4-methoxy-β-phenylethoxy-O-α-L-arabino-pyranosyl-(1′′′′→6″)-α-L-rhamnopyranosyl-(1′″→3″)-4″-O-caffeoyl-β-D-glucopyranoside(10)、leucasin A(11A)和leucasin B(11B)。结论化合物11A和11B为一对差向异构体,并且为新化合物,其余10个化合物均为首次从该属植物中分离得到。Objective To study the chemical constituents from Leucas ciliata.Methods Silica gel,RP-18,and Sephadex LH-20 column chromatography techniques were used for separation and purification of the compounds and extensive spectral analysis spectrum were employed for structural elucidation.Results Twelve compounds were isolated from ethanol extract of L.ciliata and identified as tricin（1）,crisilineol（2）,sitosterol-3-O-glucoside（3）,stigmast-5-ene-11-ol-3-O-β-glucoside（4）,5,7-dimethoxy-2methyl-4-chromanone（5）,3′,5′,5,7-tetramethoxy-4′-O-β-glucoside flavone（6）,5-hydroxy-3′,4′-dimethoxy-7-O-β-glucoside flavone（7）,acteoside（8）,3,4-dihydroxy-β-phenylethoxy-O-α-L-arabinopyranosyl-（1′′′′→2″）-α-L-rhamnopyranosyl-（1′′′→3″）-4″-O-caffeoylβ-D-glucopyranoside（9）,3-hydroxy-4-methoxy-β-phenylethoxy-O-α-L-arabinopyranosyl-（1′′′′→6″）-α-L-rhamnopyranosyl-（1′″→3″）4″-O-caffeoyl-β-D-glucopyranoside（10）,leucasin A（11A）,and leucasin B（11B）.Conclusion Compounds 11A and 11B are epimers and new compounds,and the other ten compounds are obtained from the plants of Leucas R.Br.for the first time.

关 键 词：绣球防风 差向异构体 leucasinA leucasinB 苜蓿素 

分 类 号：R284.1[医药卫生—中药学]