中药治疗2型糖尿病随机对照试验的系统评价  

Chinese Medicines for Treatment of Type 2 Diabetes:A Systematic Review of Randomized Controlled Trials

作　　者：陈威妮[1] 刘志龙[2] 张弛[3] 查青林 郭玉明[5] 姜淼[3] 吕爱平[3] 

机构地区：[1]广州中医药大学,广东广州510405 [2]广东省中医院珠海医院,广东珠海519015 [3]中国中医科学院中医临床基础医学研究所,北京100700 [4]江西中医学院数据分析中心,江西南昌330004 [5]上海中医药大学,上海201203

出　　处：《中国中医药信息杂志》2012年第1期21-24,28,共5页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金杰出青年项目(30825047);国家科技部创新方法学专项(2008IM020900);"十一五"国家科技支撑计划(N2006BAI04A10)

摘　　要：目的系统评价中药治疗2型糖尿病的疗效和安全性。方法计算机检索MEDLINE、Cochrane图书馆、中国生物医学文献数据库、中国期刊全文数据库、中文科技期刊数据库、万方数据资源系统,检索年限均从建库至2011年5月,无语种限制,选择疗程大于12周的随机对照试验(RCT)。按Cochrane系统评价方法筛选试验、评价质量、提取资料,用RevMan5.0软件对数据进行统计分析。同时,观察辨证论治理论在试验中的应用。结果总计纳入17个RCT,包括2 257例患者,质量等级为A级者1篇,其余均为C级。17个研究中应用辨证论治的有4篇。中药与饮食运动比较能显著降低空腹血糖(FBG);与西药比较可提高总有效率。有4篇文献描述了不良反应发生情况,主要为消化道症状。结论现有证据提示,中药与饮食运动比较能降低FBG,与西药比较能提高总有效率。但因纳入研究方法学质量不均,上述结论尚需更多大样本、多中心、设计严格的高质量RCT加以验证。Objective To systematically review the efficacy and safety between Chinese medicines for the treatment of type 2 diabetes mellitus （T2DM）. Methods Based on the principles and methods of Cochrane systematic reviews, we searched MEDLINE, the Cochrane Central Register of Controlled Trials, CBM, CNKI, VIP and WanFang database from inception to May 2011. We handsearched references and relevant journals. The risk of bias in the included RCTs were evaluated according to the Cochrane Handbook for Systematic Reviews. The Cochrane Collaboration’s software RevMan5.0 was used for meta-analysis. Results Seventeen RCTs involving 2 257 patients were identified. The methodological quality ranked high in 1 RCT. FBG was significant lower in Chinese medicines group than dietetic and exercise treatment, and total effective rate was higher in Chinese medicines than biomedicine. Side effects were reported in 4 articles, mainly were gastrointestinal symptoms. Conclusion There was no adequate evidence to confirm whether biomedicine can be substituted by Chinese medicines for the treatment of type 2 Diabetes mellitus. Therefore, more large-sample, multicentre, high quality RCTs to confirm this conclusion are needed.

关 键 词：中药 2型糖尿病 随机对照试验 系统评价 META分析 

分 类 号：R2-05[医药卫生—中医学] R259.871