冠状动脉造影单支病变患者血清NO及内皮素检测的临床意义  

Clinical significance of detection of serum nitric oxide and endothelin in patients with a single lesion

作　　者：王成钢[1] 朱小玲[1] 祖晓麟[1] 王春梅[1] 艾辉[1] 

机构地区：[1]首都医科大学附属北京安贞医院急诊科,100029

出　　处：《中国医药》2012年第1期5-6,共2页China Medicine

基　　金：首都医科大学基础-临床科研合作课题（10JL55）

摘　　要：目的 探讨冠状动脉造影单支病变患者血清NO及内皮素浓度变化及其意义.方法 94例冠心病患者按造影结果分为单支病变狭窄程度＞50％但＜70％组（A组,62例）及单支病变狭窄程度≥70％组（B组,32例）,选择30例造影结果阴性成年人作为对照组（C组）,检测并比较3组血清NO及内皮素浓度.结果 A组及B组患者血清NO水平均低于C组[（43±12） μmol/L,（50±11） μmol/L比（58±12） μmol/L,均P＜0.01],且B组明显高于A组（P＜0.01）；A组及B组患者血清内皮素水平均高于C组[（60±12） pg/L,（80±22） pg/L比（50±11 ）pg/L,均P＜0.01],且B组明显高于A组（P＜0.01）.结论 冠心病患者血清NO及内皮素水平与冠心病单支病变狭窄程度相关,检测冠心病患者血清NO及内皮素有助于评估患者病情及指导治疗.Objective To discuss the change and significance of plasma nitric oxide（NO） and endothelin concentrations in coronary heart disease（GHD） with one-vessel stenosis.Methods Plasma levels of NO and endothelin were measured simultaneously in 126 patients,including 62 patients with one-vessel stenosis between 50% and 70% （group A）and 32 patients 〉70% （group B）,30 patients without CHD（group C）.Results The values of plasma NO were all decreased more significantly in group A and B than those in group C [ （43 ± 12） μmol/L,（50 ± 11 ） μmol/L vs （58 ± 12） μ mol/L,P 〈 0.01 ] ; furthermore they were markedly decreased in group B than in group A （ P 〈 0.01 ）.The values of plasma endothelin were markedly higher in group A and B than those in group C[ （60 ± 12） pg/L,（80 ± 22）pg/Lvs（50 ± 11 ）pg/L,P 〈 0.01 ]; furthermore they were higher in group B than in group A （ P 〈 0.01 ）.Conclusions Metabolism disorder of NO and endothelin may lead to spasm of coronary artery.The values of plasma NO and endothelin may estimate coronary vessel＇s stenosis degree.

关 键 词：冠心病 单支病变 一氧化氮 内皮素 

分 类 号：R541.4[医药卫生—心血管疾病]