子痫前期患者血清脂氧素A4与肿瘤坏死因子α水平的变化  

Serum lipoxin A4 and tumor necrosis factor-α levels in preecliampsia patients

作　　者：董微[1] 韩玉环[1] 

机构地区：[1]天津医科大学第二医院产科,300211

出　　处：《中国医药》2012年第1期95-96,共2页China Medicine

基　　金：天津医科大学科学基金资助项目（2010ky51）

摘　　要：目的 了解不同严重程度子痫前期患者血清中脂氧素A4、肿瘤坏死因子（TNF-α）水平的变化.方法 酶联免疫吸附试验（ELISA）测定60例子痫前期患者及同期30例正常妊娠者血清中脂氧素A4及TNF-α水平,并与31例未孕者作对照.结果 正常妊娠者血清中脂氧素A4水平[（4.02±0.24） μg/L]及TNF-α水平[（4.45±0.28） μg/L]明显高于对照组[（0.69±0.11） μg/L]及[（3.22±0.23） μg/L]；轻度子痛前期患者血清脂氧素A4水平[（6.10 ±0.33） μg/L]及TNF-α水平[（7.01±0.22） g/L]明显高于正常妊娠组及对照组,重度子痫前期患者TNF-α水平[（9.11±0.21）μg/L]亦明显高于轻度子痫前期组,但脂氧素A4水平[ （2.99 ±0.15） μg/L]明显低于轻度子痫前期组及对照组.结论 子痫前期患者体内存在炎症过度反应,体内脂氧素A4是炎症拮抗物质,脂氧素A4不足是子痫前期加重的原因之一.Objective To study serum lipoxin A4 and tumor necrosis factor-α levels in different severity of preeclampsia.Methotis Serum LXA4 and tumor necrosis factor-α levels were determined by Enzyme-linked immunosorbent assay （ELISIA） in 60 case patients with preeclampsia and 30 cases of normal pregnancy during the same period.35 cases were non-pregnant as control group.Results Serum lipoxin A4 （4.02 ± 0.24） μg/L and tumor necrosis factor-α （4.45 ± 0.28 ） μg/L levels in normol pregnancy group were higher than those in control group [ （0.69 ±0.11） μg/L and （3.22 ± 0.23） μg/L] significantly.Serum lipoxin A4（6.10 ±0.33） μg/L and tumor necrosis factor-α（7.01 ±0.22）pg/L levels in mild preeclampsia group were higher than those in normal pregniancy and control group significantly.Tumor necrosis factor-αin sever preeclampsia group（9.11 ±0.21 ）μg/L was higher than that in mild preeclampsia group significantly.But serum lipoxin A4 level decreased significantly in sever preeclampsia group.Conclusions There is an excessive inflammatory response in preeclampsia patients.Lipoxin A4 is inflammatory antagonistic substances.Lack of lipoxin A4 may aggravate preeclampsia.

关 键 词：子痫 脂氧素 肿瘤坏死因子-Α 妊娠 

分 类 号：R714.2[医药卫生—妇产科学]