N端脑钠肽前体及基质金属蛋白酶-9与冠心病的相关性研究  

Study of the association of NT-proBNP and MMP-9 levels with the extent of coronary artery disease

作　　者：蒋健刚[1] 陈金国[1] 刘俊[1] 

机构地区：[1]安徽医科大学滁州临床学院,239000

出　　处：《实用医学杂志》2012年第2期221-223,共3页The Journal of Practical Medicine

摘　　要：目的:探讨N端脑钠肽前体(NT-proBNP)、基质金属蛋白酶-9(MMP-9)水平与冠心病(CAD)的相关性。方法:入选CAD患者91例,根据冠心病类型分SAP组、UAP组和AMI组;30例冠脉造影阴性者作为对照组。比较不同CAD类型病变组及与对照组之间的NT-proBNP及MMP-9水平的差异;冠脉病变支数、左主干病变程度、冠脉Gensini评分与NT-proBNP及MMP-9水平的相关性。结果:NT-proBNP、MMP-9及Gensini评分,在对照组、SAP组、UAP组及AMI组间均存在明显差异(P<0.05);与Gensini评分及病变支数呈正相关。结论:CAD患者血浆NT-proBNP及MMP-9的水平与冠脉病变严重程度之间有相关性,可作为CAD严重程度的预测指标,具有重要的临床意义。Objective To study the association of N-terminal pro-brainnatriuretic peptide （NT-proBNP） and matrixmetalloproteinase-9 （MMP-9） levels and the extent of coronary artery disease CAD. Methods 91CAD patients and 30 non-CAD patients （Control group） were included in this study.All of the subjects were verified with coronary angiography.In the light of the types of CAD ,CAD patients were assigned into three groups （SAP group, UAP group and AMI group）. The comparisons of NT-proBNP and MMP-9 levels were performed among the SAP, UAP,AMI and Control groups. The correlations of the number of impaired coronary arteries （CA）, left main coronary stenosis and Gensini scores of CA with levels of NT-proBNP and MMP-9 were compared between 4 groups. Results We found a significant association between the types of CAD and changes of NT-proBNP or MMP-9 levels. We also observed that change of NT-proBNP or MMP-9 was significantly associated with the number of vessels of suffered CA. Conclusion There exists a certain correlation between the impaired CA and the plasma levels of NT- proBNP and MMP-9 which reflects the impairment of myocardium.

关 键 词：冠心病 N端脑钠肽前体 基质金属蛋白酶-9 

分 类 号：R541.4[医药卫生—心血管疾病]