多普勒超声体内定量检测人工心瓣下游TSS方法学的实验研究  

A Methodological Study of Measuring Quantitatively Turbulent Shear Stress Downstream of artificial valve in Vivo Using Doppler Echocardiography

作　　者：张浒[1] 杨百晖[1] 张桂敏[1] 王钰[2] 李甘牛[3] 孙毅[1] 李斌[1] 

机构地区：[1]昆明医学院第一附属医院心血管外科,云南昆明650032 [2]昆明医学院第一附属医院心脏彩超室,云南昆明650032 [3]南京航空航天大学

出　　处：《中国实验诊断学》2012年第1期29-31,共3页Chinese Journal of Laboratory Diagnosis

基　　金：国家自然科学基金项目(30860279)

摘　　要：目的验证多普勒超声检测结合图形分析软件计算TSS的客观性和准确性。方法建立二尖瓣置换术动物模型,采用多普勒超声检测结合软件计算和热线流速仪实测三种人工瓣膜下游6个测量点的TSS的对比研究和相关性分析。结果 两种方法得到的TSS比较无显著性差异(P>0.05),相关分析呈正相关(r=0.91,P<0.05)。结论多普勒超声结合软件分析计算TSS是一种比较客观准确的体内无创检测TSS方法。Objective To prove the method of Doppler echocardiography combined with computerized image analysis was accurate and reliable through animal experiments. Methods The model of mitral valve replacement was established in swine to measure TSS in downstream flow field of artificial mitral valve at the same time the same location through Doppler indirectly and HFA directly. Then the two results was compared. Results There Was a positive cormlation between the results from two methods （r=0. 91,P〈0.05）. Conclusion By comparison with the HFA,the method of Doppler echocardiography combined with computerized image analysis was safe,non-invasive and accurate.

关 键 词：湍流剪应力 多普勒超声 热线流速仪 猪 二尖瓣置换 

分 类 号：R445.1[医药卫生—影像医学与核医学]