阿奇霉素分散片崩解剂优选研究  

Optimization of Screening Disintegrants for Azithromycin Dispersible Tablets

作　　者：宗永斌[1,2] 万元松 金春 秦勇[1,3] 

机构地区：[1]江苏神龙药业有限公司,盐城224260 [2]武汉大学药学院,430071 [3]江苏弘惠医药有限公司,南京210008

出　　处：《医药导报》2012年第1期72-74,共3页Herald of Medicine

摘　　要：目的为提高阿奇霉素分散片的质量,研究崩解剂对其分散性的影响。方法选择羧甲基淀粉钠、交联聚乙烯吡咯烷酮及其他适宜辅料,制备处方。结果选择羧甲基淀粉钠作崩解剂及恰当的制剂工艺可以明显提高阿奇霉素分散片的质量。结论该处方合理稳定,溶出度和分散均匀性好。Objective To study impact of disintegrants on the uniformity of tablets＇ disperse for improving the quality of azithromycin dispersible tablets. Methods Sodium earboxymethyl starch, erosslinked polyvinylpyrrolidone and other suitable ingredients were used to prepare the tablets. Results The sodium earboxymethyl starch and proper preparation significantly enhanced the quality of azithromyein dispersible tablets. Conclusion The preparation is reasonable and stable, which is evenly dispersed and well dissolved.

关 键 词：阿奇霉素分散片 羧甲基淀粉钠 交联聚乙烯吡咯烷酮 崩解剂 分散性 

分 类 号：R978.15[医药卫生—药品] TQ460.6[医药卫生—药学]