金菊消痔栓的质量标准研究  

Research of Quality Standard for Jinju Xiaozhi Suppository

作　　者：陈瑾[1] 

机构地区：[1]四川省医学科学院四川省人民医院药剂科,成都610072

出　　处：《医药导报》2012年第1期79-81,共3页Herald of Medicine

摘　　要：目的建立金菊消痔栓的质量标准。方法采用薄层色谱法鉴别金菊消痔栓中大黄、冰片;用高效液相色谱法对制剂中绿原酸进行定量分析。结果定性鉴别大黄、冰片分离度好,专属性强;绿原酸的含量测定线性范围为5.4～108.8μg(r=0.999 9,n=6),平均回收率为99.03%(RSD=1.61%,n=6)。结论该研究建立的方法准确可靠,灵敏度高,专属性强,可有效控制金菊消痔栓的质量。Objective To establish the quality standard for finju xiaozhi suppository. Methods Radix et Rhizoma Rhei and Borneolum in finju xiaozhi suppository were identified by TLC （thin layer chromatograph ）. Chlorogenic acid was determined by HPLC. Results The characteristic identification by TLC was distinct and highly specific. The results of quantitative evaluation showed that chlorogenic acid had the linear range of 5.4-108.8 μg （r= 0. 999 9 ,n= 6）, and the average recovery was 99.03% （ RSD = 1.61%, n = 6）. Conclusion The method is reliable, accurate and specific, which is benefit for the quality control offinju xiaozhi suppository.

关 键 词：金菊消痔栓 绿原酸 质量标准 色谱法 高效液相 色谱法 薄层 

分 类 号：R286[医药卫生—中药学] R927.2[医药卫生—中医学]