丙烯醛温和液相反应制备3-甲基吡啶  

Preparation Process of 3-Picoline by Mild Liquid Phase Reaction of Acrolein

作　　者：王开明[1,2,3] 潘金钢 王展旭[1] 李国强[3] 

机构地区：[1]青岛科技大学化学与分子工程学院,山东青岛266042 [2]北京华地博源生化科技有限公司,北京100120 [3]中国海洋大学医药学院,山东青岛266003

出　　处：《精细化工》2012年第1期82-85,共4页Fine Chemicals

基　　金：国家自然科学基金项目(20975094)~~

摘　　要：以丙烯醛为原料,通过单因素实验,建立了优化的温和液相反应条件,合成3-甲基吡啶的优化工艺条件为:以乙二醇单丁醚为溶剂,反应温度140℃,料比n(丙烯醛)∶n(乙二醇单丁醚)∶n(乙酸铵)=1∶33∶8,以正丁酸为稀释剂配成w(丙烯醛)=15%的正丁酸溶液,m(丙烯醛)∶m(SO42-/TiO2-HZSM-5)=1∶1.4。在优化条件下,实现了丙烯醛转化率100%,3-甲基吡啶选择性49.92%。This paper is to report an optimum preparation process of 3-picoline by mild liquid phase reaction of acrolein based on single factor design method. The reaction was carried out in the solvent of ethylene glycol monobutyl ether at 140 ℃ of temperature for 1 h,the mole ratio of aerolein and acetic ammonium and ethylene glycol monobutyl ether being 1：8：33, the mass ratio of aerolein and catalyst SO42-/TiO2-HZSM-5 being 1：1.4, and the mass percent of acrolein in n-butyric acid being 15%. Under the optimized conditions, the conversion rate of aerolein reached 100% and the yield of the selectivity of 3-picoline reached 49.92%.

关 键 词：3-甲基吡啶 丙烯醛 液相反应 工艺优化 精细化工中间体 

分 类 号：TQ253.2[化学工程—有机化工]