针刺治疗对老年卒中后抑郁患者血浆瘦素及胰岛素样生长因子-1的影响  

Effects of acupuncture on the serum leptin and IGF-1 in the elderly patients with post-stroke depression

作　　者：郭瑞友[1] 赵丽霞[1] 苏丽 王莉[1] 王彩霞[1] 郭联[1] 

机构地区：[1]青岛大学医学院附属海慈医院神经科,266033 [2]青岛市中医医院针灸科

出　　处：《国际中医中药杂志》2012年第1期15-17,共3页International Journal of Traditional Chinese Medicine

基　　金：基金项目：青岛市科技局立项课题（项目编号：06-2-2-4-nsh）

摘　　要：目的探讨针刺治疗对老年卒中后抑郁患者血浆瘦素（leptin）及胰岛素样生长因子-1（IGF-1）的影响。方法以老年缺血性卒中患者为研究对象，采用汉密尔顿抑郁量表（HAMD）筛选卒中后抑郁患者94例，按病例尾号将患者随机分为两组，全部患者均接受西医常规治疗和二级预防。对照组48例在此基础上口服舍曲林治疗，针刺组46例在对照组治疗基础上采用灵龟八法选穴治疗，两组均治疗6周。分别于治疗前后，检测患者血浆leptin和IGF-1浓度，并进行HAMD量表评估疗效。结果①治疗后针刺组血浆leptin与IGF-1浓度[分别为（17．06±12．38）ng／ml、（52．61±24．74）ng／ml]较对照组[分别为（32．27±15．09）ng／ml、（77．15±20．83）ng／m1]明显降低，差异有统计学意义（P〈0．01）。②治疗后HAMD评分，针刺组与对照组[分别为（8．06±3．32）分、（13．67±8．05）分]及6个月随访时HAMD评分[分别为（6．52±2．08）分、（10．26±6．16）分]比较，差异均有统计学意义（P〈0．01）。结论针刺治疗可降低卒中后抑郁患者血浆leptin、IGF-1浓度。Objective To investigate the effects of acupuncture on the serum leptin and IGF-1 in patients with post-stroke depression （PSD）. Methods By using Hamilton rating scale for depression （HAMD）, 94 patients with PSD were recruited and randomly divided into 2 groups： acupuncture group and control group. All patients were given routine clinical treatments and second level medical prevention. Patients in the acupuncture group received Linggui Ba fa acupuncture treatment and oral administration of Sertraline and patients in the control group were treated with oral administration of Sertraline only. Serum levels of letpin and insulin growth factor （IGF-1） were measured by enzyme linked immunosorbent assay （ELISA） before and after treatments in all patients. Results The levels of leptin and IGF-1 in patients of acupuncture group were significantly lower than that of the control group after treatment [ （17.06± 12.38）ng/mt vs （32.27 ±15.09）ng/ml, P〈0.01; （52.61±24.74）ng/ml vs （77.15±20.83）ng/ml, P〈0.01 respectively]. The scores of HAMD in acupuncture group were significantly lower than that of control group after the treatment[ （8.06±3.32）、 （13.67±8.05） ] and 6 month later[ （6.52±2.08）, （10.26±6.16） ]. Conclusion The serum levels of leptin and IGF-1 were significantly lower and depression symptoms were improved after acupuncture in elderly patients with post-strok depressin.

关 键 词：卒中后抑郁 针刺 瘦素 胰岛素样生长因子-1 

分 类 号：R246[医药卫生—针灸推拿学]