口蹄疫灭活疫苗对不同亚洲Ⅰ型病毒株的交叉保护效果  

The Cross Protection Effect of Foot-and-mouth Disease Inactivated Vaccine Against the Different AsiaⅠ Strains

作　　者：黄炯[1,2,3] 李一经[1] 王力俭[2] 朱刚 王延[2,3] 刘宏 张莉 薛英[2] 魏玉荣[2] 易中[2] 魏婕[2] 徐亚萍 王莉君 

机构地区：[1]东北农业大学动物医学学院,黑龙江哈尔滨150030 [2]新疆畜牧科学院兽医研究所,新疆乌鲁木齐830000 [3]新疆天康畜牧生物技术股份有限公司,新疆乌鲁木齐830032

出　　处：《草食家畜》2011年第4期62-64,共3页Grass-Feeding Livestock

基　　金：农业公益性行业科研专项(编号200803026);新疆高技术研究发展计划项目(编号200911111)资助

摘　　要：分别用亚洲Ⅰ型Asia-1 KZ/03毒株和AsiaⅠ/JSL毒株按口蹄疫灭活疫苗相关生产规程配制口蹄疫O型、亚洲Ⅰ型二价灭活疫苗免疫动物,检测2种毒株的攻毒保护效果。结果显示,用Asia-1 KZ/03株病毒配制的口蹄疫O型、亚洲Ⅰ型二价灭活疫苗用同源病毒株攻击,保护效果可达7.05PD50/头份,用异源病毒株Asia1/JSL/GSZY/06攻击,保护效果可达7.19PD50/头份;用AsiaⅠ/JSL株病毒配制的口蹄疫O型、亚洲Ⅰ型二价灭活疫苗对江苏毒同源毒株Asia1/JSL/GSZY/06攻击,保护效果可达7.29 PD50/头份。说明,用Asia-1 KZ/03病毒株制备的疫苗对Asia1/JSL/GSZY/06病毒具有良好的交叉保护效果,可达到同源病毒株制备疫苗的免疫效果。To evaluate the relation of vaccine virus strain of Foot and Mouth Disease virus （FMDV） inactivated vaccine, a batch of FMDV inactivated vac, cine was compounded respectively with Asia-1 KZ / 03 strain and Asia I/JSL strain according to related regulations and immune animals. The results of challenge protection efficiency of the homologous virulent strain showed that Asia-1 KZ / 03 strain was 7.05 PD50 for the FMD Bivalent Inactivated Vaccine（Type O and Asial ,OHM/02 ＋Asia I KZ/03）, and Asial / JSL/GSZY / 06 strain was 7.29 PDso for the FMD Bivalent Inactivated Vaccine （Type O and Asial ,OHM/02 ＋Asia I/ JSL）; the FMD Bivalent Inactivated vaccine （Type O and Asial ,OHM/02 ＋Asia [ KZ/03） resistances to the hierology virulent strain of type Asial （Asial/JSL/GSZY/06 stain） was 7.19 PDso. With that, the vaccine preparation with Asia-I KZ / 03 virus strains against the Asial / JSUGSZY / 06 virus has a good crossprotection effect, can achieve cross homologous strains of the vaccine preparation immunity effect

关 键 词：口蹄疫 灭活疫苗 亚洲I型 Asia-1 KZ/03毒株 Asial/JSL/GSZY/06毒株 

分 类 号：S859.797[农业科学—临床兽医学]