正常成年SD大鼠脑内CXCR4免疫阳性细胞的形态学观察  

Morphological observation of CXCR4 immnopositve cell of brain in normal adult rat

作　　者：袁红海[1] 潘三强[1] 王海树[1] 宿宝贵[1] 

机构地区：[1]暨南大学医学院人体解剖学系,广东广州510632

出　　处：《解剖学研究》2011年第6期409-412,共4页Anatomy Research

摘　　要：目的研究成年大鼠脑内表达CXCR4细胞的形态学特征。方法用免疫组织细胞化学方法对成年大鼠脑内表达CXCR4细胞的分布和形态特点。结果在成年大鼠脑内,CXCR4免疫阳性细胞广泛分布于新皮质各层和各区。在皮层上,外颗粒层阳性细胞相对比较集中,形成一个深染的阳性细胞带,而其它各层阳性细胞比较分散。在各区皮质,如压部皮质、额叶、顶叶、嗅皮质区以及杏仁周皮质区。在皮质下区,CXCR4免疫阳性细胞相对集中见于第三脑室脉络丛、室管膜和内、外侧僵核、室周灰质、丘脑核群、外侧膝状体核、尾壳核、下丘脑室旁核、视上核。在古旧皮质区,主要见于海马结构和杏仁复合体区。结论正常大鼠脑表达CXCR4细胞除文献报道的脑区和核团细胞外,第三脑室脉络丛、室管膜、僵核、海马结构以及杏仁复合体等古旧皮质区内有细胞表达。Objective To study morphological feature of expression CXCR4 cell of adult brain in rats.Methods Immunohisochemistry was used to identiy cells of expression CXCR4 and light microscopy was used to observe their distribution and shape.Results In normal adult rat brain cells of expression CXCR4 distributed all neocortex each layer and each region.In external granular layer cells of CXCR4 immunopositive were more concentration and make cell band but in other layer the positive cell was distracted by varies ship.In the neocotex region,CXCR4 positive cell were seen,for example,frontal cortex,parietal cortex,temporal cortex,and amygdaloid cortex.In subcortal region,there were many cells of expression CXCR4,for example,third paraventricular gray,choroid plexuses,ventricular tube membrane,medial and lateral hebunular nucle,paraventricular and supraoptical nucleus of hypothalamus,thalamus neuclei complex,and lateral geniculate bodies,globul pallidus and putamen.In archi-paleocortex,hippocampal formation and amygloid complex body were expression CXCR4.Conclusion In normal rat brain expression CXCR4 cells are show in choroid plexuses,ventricular tube membrane,habenular nuclei and hippocampal formation as well as amygdaloid complex bodies except reported brain region and nuclei.

关 键 词：CXCR4 脑 大鼠 免疫组织化学 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]