高龄老年舒张性心力衰竭患者N末端脑利钠肽原和C反应蛋白的变化及其意义  

Diagnostic and therapic evaluations of N-terminal pro B-type natriuretic peptide and C-reactive protein in geriatric diastolic heart failure(≥80 Years of Age)

作　　者：卓胜青[1] 陈勇驰[1] 曾平[1] 杨辉剑[1] 连环[1] 

机构地区：[1]广东省人民医院广东省医学科学院广东省老年医学研究所,广东广州510080

出　　处：《解剖学研究》2011年第6期445-446,478,共3页Anatomy Research

摘　　要：目的测定高龄老年人(≥80岁)舒张性心力衰竭(DHF)患者治疗前、后血N末端脑利钠肽原(NT-ProBNP)和C反应蛋白(CRP)的水平,探讨高龄老年DHF患者NT-ProBNP和CRP的变化及其意义。方法经临床治疗后心力衰竭明显改善的高龄老年DHF患者42例作为研究对象,并选取心功能正常的高龄老年人38例作为对照组。监测DHF患者治疗前、后的血NT-ProBNP和CRP水平。结果高龄老年DHF患者的NT-ProBNP和CRP值明显高于对照组(P<0.01);高龄老年DHF患者治疗后NT-ProBNP和CRP均显著下降(P<0.01)。结论血浆NT-ProBNP和CRP在高龄老年DHF患者中明显升高,NT-ProBNP和CRP的变化对高龄老年DHF患者疗效观察和病情转归有一定的临床价值。Objective To analyze the change and significance of plasma N-terminal pro B-type natriuretic peptide（NT-ProBNP） and serum C-reactive protein（CRP） in geriatric diastolic heart failure（DHF） and further illustrate clinical value measuring plasma NT-ProBNP and serum CRP at the same time.Methods Collected 42 geriatric DHF patients as research target which heart function was obviously improved by clinical treatment.38 patients of normal cardiac function as control group.Plasma NT-ProBNP and serum CRP levels were measured before and after treatment in geriatric DHF groups.Results The level of plasma NT-ProBNP and serum CRP in geriatric DHF were significantly higher than that in control group（P 0.01）.Plasma NT-ProBNP and serum CRP in geriatric DHF patients were significantly decreased by clinical treatment（P 0.01）.Conclusion The levels of plasma NT-ProBNP and serum CPR in geriatric DHF were significantly higher than those in control group.The levels of plasma NT-ProBNP and serum CPR coincided with the levels of geriatric DHF.

关 键 词：舒张性心力衰竭 N末端脑利钠肽原 C反应蛋白 

分 类 号：R541.6[医药卫生—心血管疾病]