糖皮质激素短期治疗对慢性阻塞性肺疾病急性加重期患者血清IL-1β、IL-1Ra的影响  

Influences of the short-term treatment with glucocorticoid on serum IL-1β and IL-1Ra in patients with acute exacerbation of chronic obstructive pulmonary disease

作　　者：田景伦 闫芳[1] 康定理 何书经 刘霞[1] 漆自立[2] 

机构地区：[1]成都市温江区人民医院,四川成都611130 [2]四川省人民医院,四川成都610072

出　　处：《中国医院药学杂志》2012年第1期5-8,共4页Chinese Journal of Hospital Pharmacy

基　　金：四川省卫生厅科研课题(编号:060203)

摘　　要：目的:研究糖皮质激素短期治疗对慢性阻塞性肺疾病急性加重期(AECOPD)患者血清IL-1β和IL-1Ra的影响,初步探讨糖皮质激素治疗AECOPD患者抗炎症作用的机制。方法:选取38例AECOPD患者随机分为糖皮质激素组和对照组,用酶联免疫吸附试验(ELISA)检测并比较治疗前后2组患者的血清IL-1β、IL-1Ra水平。结果:治疗前血清IL-1β、IL-1Ra和IL-1β/IL-1Ra比值在2组间比较,差异无统计学意义(P>0.05);治疗后,其差异有统计学意义(P<0.05)。结论:糖皮质激素短期治疗AECOPD患者,发挥作用的机制之一是其抑制前炎症因子IL-1β释放的同时还促进抗炎症因子IL-1Ra的表达即下调IL-1β/IL-1Ra比值。OBJECTIVE To explore the influences of the short-term therapy with glucocorticoid on serum IL-1β and IL-1Ra , and reveal it＇s anti-inflammatory mechanisms of action in patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. METHODS 38 patients with AECOPD were randomLy divided into glucocorticoid group and control group,and the levels of IL-1β,IL-1Ra in serum were tested and compared by enzyme linked immunosorbent assay （ELISA）before and after the treatment. RESULTS There were no significant differences between two groups in IL-1β、IL-1Ra and IL-1β/IL-1Ra ratio before treatment （P〉0. 05）, mean while, there were statistically significant differences between the two groups after treatment （P〈0. 05）. CONCLUSION The study suggests that short-term treatment with glucocorticoid may play an important role not only by inhibiting inflammatory cytokine IL-1β release, but also by promoting anti-inflammatory cytokine IL-1Ra expression, which increasing the ratio of IL-1β/IL-1Ra in patients with AECOPD.

关 键 词：糖皮质激素 慢性阻塞性肺疾病 白介素-1Β 白介素-1受体拮抗剂 细胞因子 治疗 

分 类 号：R971.1[医药卫生—药品]