3-乙基-5-吡唑羧酸乙酯的合成研究  

Synthesis of ethyl 3-ethyl-5-pyrazolecarboxylate

作　　者：刘志勇 叶小东[2] 江洪[2] 

机构地区：[1]江苏剑牌农药化工有限公司,江苏盐城224700 [2]华中农业大学化学系,湖北武汉430070

出　　处：《化学试剂》2012年第1期83-84,87,共3页Chemical Reagents

摘　　要：3-乙基-5-吡唑羧酸乙酯是新型杀螨剂吡螨胺的关键中间体,传统的合成方法副反应多、产率低、反应速率慢,探索了用乙酸做催化剂,高效方便地合成了目标产物。同时研究了乙酸做催化剂时合成目标产物的最佳条件。实验结果表明,在丙酰丙酮酸乙酯、乙酸与水合肼的物质的量比为1∶2∶1.2,反应时间4 h,反应温度0～5℃时,收率达到98.53%,纯度达到96.2%。Ethyl 3-ethyl-5-pyrazolecarboxylate, which is a key intermediate for tebufenpyrad, was synthesized using acetic acid as catalyst in higher yield, faster rate and less by-product than traditional method. The optimal experimental conditions were obtained. Under 0 -5 ℃ for 4 h,with a 1： 2：1.2 molar ratio of ethylpropionylpyruvate, acetic acid and hydrazine hydrate,the optimized yield of 98.53% and purity of 96. 2% were obtained.

关 键 词：乙酸 催化 吡螨胺 3-乙基-5-吡唑羧酸乙酯 

分 类 号：O626.21[理学—有机化学]