2-(N-烷基胺甲酰基)-4-甲氧基吡啶的合成与表征  

Synthesis and characterization of 4-methoxy-2-N-alkyl carbamoyl pyridine

作　　者：闫凤美[1] 牛建兵[1] 潘庆才[1] 

机构地区：[1]黄淮学院化学化工系,河南驻马店463000

出　　处：《化学试剂》2012年第1期91-93,共3页Chemical Reagents

基　　金：河南省基础与前沿技术研究项目(082300420-120)

摘　　要：4-氯-2-吡啶甲酸甲酯与异丙胺、正丁胺通过胺解反应,制得相应的取代胺基甲酰基吡啶后,再与甲醇钠通过Wil-liamson合成法,得到标题化合物;详细考察了溶剂、反应温度对反应的影响;产品结构经IR、1HNMR、ESI-MS表征。Two 4-methoxy-2-N-alkyl carbamoyl pyridines were prepared from Williamson reaction between sodium methoxide and 4-chloropyridyl-2-formyl amide intermediates, which were synthesized starting from 4-chloropyridyl-2-earboxylie acid methyl ester, isopropylamine and butylamine. The effects of solvents and temperatures on the reaction were invisitigated. The structures of the compounds were confirmed by IR, 1HNMR and ESI-MS.

关 键 词：4-氯-2-吡啶甲酸甲酯 胺解 Williamson合成法 2-(N-烷基胺甲酰基)-4-甲氧基吡啶 合成 表征 

分 类 号：TQ463[化学工程—制药化工]