冠状动脉粥样硬化、冠状动脉痉挛患者血清C-反应蛋白的检测  

The level of C-reactive protein in serum of patients with coronary atherosclerosis and coronary artery spasm

作　　者：郭学荣[1] 岳霞[2] 

机构地区：[1]广州市公安局萝岗区分局,广东广州510530 [2]南方医科大学

出　　处：《中外医学研究》2012年第1期43-45,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的 检测急性冠脉综合征(ACS)患者血清C-反应蛋白(CRP)水平,探讨不同病理机制ACS患者血清CRP的变化对其发病及病情预测的意义。方法 在2009年3月～2010年3月以ACS入院的心内科患者中,经冠状动脉造影,选取30例冠状动脉粥样硬化斑块破裂并血栓形成的患者为CHD组,选取30例冠状动脉未见明显狭窄、诊断为冠状动脉痉挛的患者为CAS组,选取同期健康志愿者30例为空白对照组。试验组入院即抽取肘静脉血,对照组抽取清晨空腹静脉血,测定血清CRP含量,分析CRP变化。结果 CHD组患者血清CRP与CAS组无显著差异性,CHD组、CAS组患者血清CRP均与对照组有显著差异性。结论 CRP水平升高与ACS、CAS的发生有相关性;冠脉炎症可导致ACS,但与冠状动脉粥样硬化程度无关。Objective To determine the level of C - reactive protein （CRP） in serum of patients with acute coronary syndrome, explore the relationship between CRP and coronary atheroselerosis, coronary artery spasm （CAS）. Methods Patients with acute coronary syndrome （ACS） to be in the department of cardiology from May 2009 to May 2010. After coronary angiography,30 cases with coronary stenosis at least IU degree,named CHD group ,30 cases without obviously coronary stenosis and diagnosis CAS, named CAS group. Meanwhile, 30 eases of healthy people were enrolled during physical examination as blank control group. Venous blood was colleted when they came to hospital of test groups, venous blood in the morning was collected of control group for the determination of serum CRP level and observation of CRP changes. Results CRP level in CHD group was not significantly difference compared with CAS group. Significantly difference presented in serum CRP level in comparison of CHD group and CAS group with control group. Conclusion CRP level is relevant with ACS and CAS. Inflammation is relevant with ACS, but CRP level is not relevant with the severity of coronary stenosis.

关 键 词：急性冠脉综合征 冠状动脉粥样硬化 冠状动脉痉挛 C-反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]