太白七药红毛七化学成分研究  

Study on the Chemical Constitutes of C.robustum root

作　　者：马养民[1] 邢华[1] 刘建军[2] 康永祥[2] 

机构地区：[1]陕西科技大学化学与化工学院教育部轻化工助剂化学与技术重点实验室,陕西西安710021 [2]西北农林科技大学林学院,陕西杨凌712100

出　　处：《安徽农业科学》2012年第2期745-747,共3页Journal of Anhui Agricultural Sciences

基　　金：林业公益性行业科研专项(200904004);陕西省科学技术研究发展计划项目(2009K02-02)

摘　　要：[目的]研究太白七药红毛七的化学成分,为其药效成分及作用机理的深入研究奠定基础。[方法]采用硅胶柱色谱、SephadexLH-20、重结晶等方法进行分离纯化,依据理化性质和波谱数据进行结构鉴定。[结果]从红毛七石油醚及乙酸乙酯萃取相中分离得到9个纯品化合物,分别为棕榈酸(Ⅰ)、α-菠菜甾醇(Ⅱ)、α-菠甾醇-β-D-葡萄糖苷(Ⅲ)、β-豆甾醇(Ⅳ)、16α,23,28-三羟基-齐墩果-12-烯-3-O-α-L-阿拉伯吡喃糖苷(Ⅴ)、16α-羟基-齐墩果-12-烯-28-酸-3-O-α-L-阿拉伯吡喃糖苷(Ⅵ)、常春藤皂苷元-3-O-α-L-阿拉伯吡喃糖苷(Ⅶ)、葳严仙皂苷元-3-O-α-L-阿拉伯吡喃糖苷(Ⅷ)、常春藤皂苷元-3-O-β-D-葡萄吡喃糖-(1→2)-α-L-阿拉伯吡喃糖苷(Ⅸ);化合物Ⅰ、Ⅱ、Ⅲ、Ⅴ均为首次从该属植物中分离得到。[结论]该方法可用于研究太白七药红毛七的化学成分,为太白山产红毛七的进一步开发利用提供依据。[Objective] To study the chemical constitutes of C.robustum root,thus to supply evidence for its pharmacological research and therapeutic mechanism.[Method] The chemical constitutes were isolated from C.robustum root by silical gel column chromatography,SephadexLH-20 and recrystallization,and their strctures were elucidated on the basis of spectral analysis and physicochemical property.[Result] Nine compounds were isolated from the ethyl acetate extract of C.robustum root,and their structures were identified as palmitic acid（I）,α-spinasterol（II）,α-spinasteryl-3-O-β-D-glucoside（III）,β-stigmasterol（IV）,16α,23,28-trihydroxy-olean-12-en-3-O-α-L-arabinopyranoside（V）,16α-hydroxy-olean-12-en-28 oic acid-3-O-α-L-arabinopyranoside（VI）,hederagenin-3-O-α-L-arabinopyranoside（VII）,caulophyllogenin-3-O-α-L-arabinopyranoside（VIII）,hederagenin-3-O-β-D-glucopyranosyl-（1→2）-α-L-arabinopyranoside（IX）.Of them,compound I,II and III were isolated from this plant for the first time.[Conclusion] This method could be used for studying the chemical constitutes of C.robustum root,and the study provides basis for the further development and utilization of C.robustum.

关 键 词：红毛七(ROOT OF BLUE COHOSH) 化学成分 甾醇 糖苷 

分 类 号：R284.1[医药卫生—中药学]