210例HIV/AIDS患者淋巴细胞计数与机会性感染相关分析  

Correlation analysis between lympocyte counts and opportunistic infections in 210 cases of HIV/AIDS patients

作　　者：许超宇[1] 张宇锋[2] 朱宇佳[1] 陈昌枝[1] 覃琼芬[1] 梁世寅[1] 李仕雄[1] 

机构地区：[1]广西医科大学第八附属医院,广西贵港537100 [2]中山大学附属第三医院,广东广州510630

出　　处：《热带医学杂志》2011年第12期1385-1387,共3页Journal of Tropical Medicine

基　　金：广西贵港市科技攻关项目(贵科攻0908006)

摘　　要：目的分析HIV/AIDS患者总淋巴细胞计数(TLC)与机会性感染的关系,为HIV/AIDS患者机会性感染的治疗及一级、二级预防提供参考依据。方法对2009年6月至2011年5月210例HIV/AIDS患者的淋巴细胞及出现的机会性感染进行分析。将患者分为TLC>1300个/μl组(G1组)和TLC≤1300个/μl组(G2组),比较两组患者机会性感染发生率的差异。结果 210例HIV/AIDS患者机会性感染的总感染率为86.7%,主要的机会性感染为口腔念珠菌感染(56.2%)、细菌性肺炎(46.7%)、肺结核(42.4%)、败血症(21.4%)、感染性腹泻(20.5%)。G2组患者机会性感染的发生率为93.6%,高于G1组患者(55.3%),差异有统计学意义(P<0.05);随着TLC的下降,患者发生机会性感染的机率增高。结论 HIV/AIDS患者机会性感染的发生率高,TLC是HIV/AIDS患者发生机会性感染的独立危险因素。因此,应定期监测HIV/AIDS患者TLC,加强患者机会性感染的一级和二级预防。Objective The aim of this study was to analyze the relation between lymphocyte counts and opportunistic infections in HIV/AIDS patients in order to provide reference for the treatment, primary and secondary prophylaxis for HIV/ AIDS patients with opportunistic infections. Methods The total infection rate and type of 210 patients with HIV/AIDS were analyzed. According to lymphocyte counts, patients were divided into two groups： lymphocyte counts more than 1 300 / l and less than 1 300 / l. Differences of infection rate of opportunistic infections between two groups were compared. Results The total infection rate of opportunistic infections in 210 cases of HIV/AIDS patients was 86.7%.The major opportunistic infections were oral candidiasis （56.2%）, bacterial pneumonia （46.7%）, tuberculosis （42.4%）, sepsis（21.4%） and infectious diarrhea （20.5%）. The infection incidence in the group of patients with lymphocyte counts less than 1 300/ l （93.6%） was significantly higher than that of patients with lymphocyte counts more than 1 300 / l （55.3%）（P0.05）. With the decline of lymphocyte counts,the incidence of opportunistic infections increased. Conclusions HIV/AIDS patients have a high incidence of opportunistic infections. Lymphocyte counts was an independent risk factor of opportunistic infections in HIV/AIDS patients. Therefore, lymphocyte counts of HIV/AIDS patients should be monitored regularly to strengthen the primary and secondary prophylaxis of opportunistic infections.

关 键 词：HIV/AIDS患者 机会性感染 总淋巴细胞计数 

分 类 号：R512.91[医药卫生—内科学]